粉蝶霉素A
基本信息
| 产品名称 | 粉蝶霉素A |
|---|---|
| 英文名称 | Piericidin A |
| 英文别名 | Piericidin A1;Shaoguanmycin B;SN 198E;AR-054;2-(10-hydroxy-3,7,9,11-tetramethyl-2,4,7,11-tridecatetraenyl)-5,6-dimethoxy-3-methyl-4-pyridinol |
| 规格或纯度 | ≥95% |
| 运输条件 | 超低温冰袋运输 |
一般描述
粉蝶霉素A是一种抗生素，也是I类抑制剂的成员。Piericidin A可以有效抑制I型细菌和线粒体NADH-泛醌氧化还原酶（复合物I）。作为NADH脱氢酶的抑制剂，Piericidin A抑制电子转移。研究表明，Piericidin A阻止NADH内源性泛醌还原酶反应中NADH诱导的质子的移位，并且Piericidin A在复合物I的NUOD-NUOB界面附近结合。PiericidinA也被称为AR-054，Shaoguanmycin B ，抗生素MT 1882-I，SN 198E和2-[（（2E，5E，
Piericidin A is an antibiotic and a member of the Class I inhibitors. Piericidin A acts as an effective inhibitor of the bacterial and mitochondrial type I NADH-ubiquinone oxidoreductases (Complex I). As an inhibitor of NADH dehydrogenase, Piericidin A inhibits electron transfer. Research indicates that Piericidin A prevents the translocation of the NADH-induced proton in the NADH-endogenous ubiquinone reductase reaction, and that Piericidin A binds near the NUOD-NUOB interface of Complex I. Piericidin A is also known as AR-054, Shaoguanmycin B, Antibiotic MT 1882-I, SN 198E, and 2-[(2E,5E,7E,9R,10R,11E)-10-Hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-5,6-dimethoxy-3-methyl-4(1H)-pyridinone.
相关属性
| CAS编号 | 2738-64-9 |
|---|---|
| 折光率 | n20D1.53 (Predicted) |
| 熔点 | 220.48° C (Predicted) (tautomer) |
| 沸点 | ~591.7° C at 760 mmHg (Predicted) (tautomer) |
| pKa值 | pKa: 5.22 (Predicted), pKa: 10.17 (Predicted) |
| 溶解性 | Soluble in 100% ethanol, DMF, DMSO, and water (poorly). |
| 储存温度 | -20°C储存 |
| RTECS | YD4588000 |
| 密度 | ~1.1 g/mL (Predicted) (tautomer) |
| 分子量 | 415.57 |
| 分子式 | C25H37NO4 |
| 品牌 | Jinpan |
| Smiles | C/C=C(\\C)/[C@@H]([C@H](C)/C=C(\\C)/C=C/C/C(=C/CC1=C(C(=O)C(=C(N1)OC)OC)C)/C)O |
| IC50 | L929: IC₅₀= 0.43 nM (mouse); Mitochondrial complex I; NADH oxidoreductase: IC₅₀= 5 nM (bovine) |
| PubChem CID | 6437838 |