上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
McMMAF (Synonyms: Maleimidocaproyl monomethylauristatin F) 纯度: 99.58%
McMMAF 是由高效微管抑制剂 Monomethyl auristatin F (MMAF) 与保护基团 maleimidocaproyl 偶联而成。MMAF 为抗微管蛋白化合物,能通过阻断微管聚合抑制细胞分裂,较 MMAE 毒性低,可用于抗体偶联药物 (ADC)。
McMMAF Chemical Structure
CAS No. : 863971-19-1
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
Free Sample (0.1-0.5 mg) | Apply now | ||
5 mg | ¥1350 | In-stock | |
10 mg | ¥2250 | In-stock | |
25 mg | ¥4950 | In-stock | |
50 mg | ¥8550 | In-stock | |
100 mg | ¥13050 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor. |
||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IC50 & Target |
|
||||||||||||||||
体外研究 (In Vitro) |
MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||
分子量 |
925.16 |
||||||||||||||||
Formula |
C49H76N6O11 |
||||||||||||||||
CAS 号 |
863971-19-1 |
||||||||||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
储存方式 |
-20°C, stored under nitrogen *该产品在溶液状态不稳定,建议您现用现配,即刻使用。 |
||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : ≥ 100 mg/mL (108.09 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
||||||||||||||||
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务