STL127705

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

STL127705  纯度: ≥98.0%

STL127705 (Compound L) 是一种 Ku 70/80 异二聚体蛋白 (Ku 70/80 heterodimer protein) 抑制剂,抑制 Ku70/80-DNA 相互作用,IC50 值为 3.5 μM。STL127705 可抑制 Ku 依赖性 DNA-PKCS 激酶的活化,IC50 值为 2.5 μM。

STL127705

STL127705 Chemical Structure

CAS No. : 1326852-06-5

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5 mg ¥3500 In-stock
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50 mg ¥16500 In-stock
100 mg ¥22500 In-stock
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STL127705 相关产品

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生物活性

STL127705 (Compound L) is a Ku 70/80 heterodimer protein inhibitor, inhibits Ku70/80-DNA interaction, with an IC50 of 3.5 μM. STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 μM)[1].

IC50 & Target

IC50: 3.5 μM (Ku 70/80), 2.5 μM (DNA-PKCS)[1]

分子量

437.42

Formula

C22H20FN5O4

CAS 号

1326852-06-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : < 0.1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*STL127705 is usually formulated as a suspension.

参考文献
  • [1]. Weterings E, et al. A novel small molecule inhibitor of the DNA repair protein Ku70/80. DNA Repair (Amst). 2016 Jul;43:98-106.

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