BI-3802

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BI-3802  纯度: 99.43%

BI-3802 是一种高效的 BCL6 降解剂，能够抑制 BCL6 的Bric-à-brac (BTB) 结构域，IC50 值 ≤3 nM。BI-3802 可诱导 BCL6 蛋白聚集，并促进 E3 连接酶 SIAH1 介导的蛋白降解。BI-3802 具有抗肿瘤活性。

BI-3802

BI-3802 Chemical Structure

CAS No. : 2166387-65-9

规格 价格 是否有货 数量
5 mg ￥3800 In-stock
10 mg ￥6400 In-stock
50 mg   询价  
100 mg   询价  

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BI-3802 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Anti-Cancer Compound Library
  • Chemical Probe Library
  • Anti-Blood Cancer Compound Library
  • Transcription Factor Targeted Library

生物活性

BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 of ≤3 nM. BI-3802 induces the polymerization of BCL6 and promotes BCL6 degration depended on E3 ligase SIAH1. BI-3802 has antitumor activity[1][2].

IC50 & Target

IC50: ≤ 3 nM (BCL6 BTB)[1]
体外研究
(In Vitro)

BI-3802 shows an IC50 of 43 nM for the cellular BCL6[1].
BI-3802 increases the interaction between BCL6 and SIAH1 (EC50 = 64 nM)[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

484.98

Formula

C24H29ClN6O3
CAS 号

2166387-65-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 5 mg/mL (10.31 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0619 mL 10.3097 mL 20.6194 mL
5 mM 0.4124 mL 2.0619 mL 4.1239 mL
10 mM 0.2062 mL 1.0310 mL 2.0619 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kerres N, et al. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep. 2017 Sep 19;20(12):2860-2875.

    [2]. Mikołaj Słabicki, et al. Small-molecule-induced polymerization triggers degradation of BCL6. Nature. 2020 Nov 18.

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