Pomalidomide 4′-PEG5-acid(Synonyms: Pomalidomide-PEG5-CO2H)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Pomalidomide 4′-PEG5-acid (Synonyms: Pomalidomide-PEG5-CO2H) 纯度: 95.02%

Pomalidomide 4′-PEG5-acid (Pomalidomide-PEG5-CO2H) 是一种合成的 E3 连接酶配体-linker 偶联物 (E3 ligase ligand-linker conjugate),包含基于 Pomalidomide 的 cereblon 配体和 5 个单元 PEG 的 linker。

Pomalidomide 4

Pomalidomide 4′-PEG5-acid Chemical Structure

CAS No. : 2139348-63-1

规格 价格 是否有货 数量
50 mg ¥4000 In-stock
100 mg ¥6500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Pomalidomide 4′-PEG5-acid (Pomalidomide-PEG5-CO2H) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 5-unit PEG linker used in PROTAC technology[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

565.57

Formula

C26H35N3O11

CAS 号

2139348-63-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

参考文献
  • [1]. [1]Jing Liu, et al. Cyclic-amp response element binding protein (cbp) and/or adenoviral e1a binding protein of 300 kda (p300) degradation compounds and methods of use. WO2020173440A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务