Lipoic acid PEG Aminooxy (Lipoic acid-PEG-ONH2) is one of Nanocs carbonyl reactive PEG derivatives that have a lipoic acid group on one end of PEG and an aminooxy group (-ONH2) on the other terminus. Lipoic acid, also known as thioctic acid, contains a disufide bond that can bind to gold and other metal surface. It is also an important molecule parting in various biological processes. Aminooxy group (-ONH2), on the other hand, can react with aldehyde or ketone groups derived from polysaccarides or glycoproteins. Reaction between aminooxy and ketone group results in a stable oxime linkage, which is more stable than the schiff base formed between amine and ketone group.
Product Specification:
Form: Solid powder or semi-solid depends on PEG length
DBCO PEG acid, MW 1000, 2000, 3400, 5000, 10000 Da:
Nanocs’ DBCO (dibenzocyclooctyne) PEG acid, DBCO-PEG-COOH, is a heterobifunctional reactive PEG derivative that can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneously without the need for toxic Cu catalysts. Carboxylic acid group, on the other hand, can be activated to react with amines, hydroxy and other functional groups.
Nanocs DBCO PEG acid features:
Appearance: Off-white solid or semi-solid depends on MW of PEG;
Solubility: Soluble in water, DMSO and chloroform;
Reactivity: DBCO reactive to azide group while acid group reactive to amine and hydroxy groups.
Copper-free Click reaction procedures:
Prepare the azide-containing reagents in reaction buffer.
Add DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
Purify conjugates either by dialysis or size-exclusion chromatograph.
Storage Conditions:
Store at -20 0C, desiccate. Protect from light. Avoid frequent thaw and freeze.
DBCO PEG acid, MW 1000, 2000, 3400, 5000, 10000 Da:
Nanocs’ DBCO (dibenzocyclooctyne) PEG acid, DBCO-PEG-COOH, is a heterobifunctional reactive PEG derivative that can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneously without the need for toxic Cu catalysts. Carboxylic acid group, on the other hand, can be activated to react with amines, hydroxy and other functional groups.
Nanocs DBCO PEG acid features:
Appearance: Off-white solid or semi-solid depends on MW of PEG;
Solubility: Soluble in water, DMSO and chloroform;
Reactivity: DBCO reactive to azide group while acid group reactive to amine and hydroxy groups.
Copper-free Click reaction procedures:
Prepare the azide-containing reagents in reaction buffer.
Add DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
Purify conjugates either by dialysis or size-exclusion chromatograph.
Storage Conditions:
Store at -20 0C, desiccate. Protect from light. Avoid frequent thaw and freeze.
DBCO PEG acid, MW 1000, 2000, 3400, 5000, 10000 Da:
Nanocs’ DBCO (dibenzocyclooctyne) PEG acid, DBCO-PEG-COOH, is a heterobifunctional reactive PEG derivative that can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneously without the need for toxic Cu catalysts. Carboxylic acid group, on the other hand, can be activated to react with amines, hydroxy and other functional groups.
Nanocs DBCO PEG acid features:
Appearance: Off-white solid or semi-solid depends on MW of PEG;
Solubility: Soluble in water, DMSO and chloroform;
Reactivity: DBCO reactive to azide group while acid group reactive to amine and hydroxy groups.
Copper-free Click reaction procedures:
Prepare the azide-containing reagents in reaction buffer.
Add DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
Purify conjugates either by dialysis or size-exclusion chromatograph.
Storage Conditions:
Store at -20 0C, desiccate. Protect from light. Avoid frequent thaw and freeze.
Folic acid PEG derivatives are a class of bioactive PEGs that can be used to for drug delivery or bioassay development. Folic acid has high affinity towards folate receptor, a cell membrane receptor that can be used for targeted drug delivery.
Physical Properties:
Yellow solid or viscous liquid depends on molecule weight;
Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Folic acid PEG derivatives are a class of bioactive PEGs that can be used to for drug delivery or bioassay development. Folic acid has high affinity towards folate receptor, a cell membrane receptor that can be used for targeted drug delivery.
Physical Properties:
Yellow solid or viscous liquid depends on molecule weight;
Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Folic acid PEG derivatives are a class of bioactive PEGs that can be used to for drug delivery or bioassay development. Folic acid has high affinity towards folate receptor, a cell membrane receptor that can be used for targeted drug delivery.
Physical Properties:
Yellow solid or viscous liquid depends on molecule weight;
Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Folic acid PEG derivatives are a class of bioactive PEGs that can be used to for drug delivery or bioassay development. Folic acid has high affinity towards folate receptor, a cell membrane receptor that can be used for targeted drug delivery.
Physical Properties:
Yellow solid or viscous liquid depends on molecule weight;
Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Folic acid PEG derivatives are a class of bioactive PEGs that can be used to for drug delivery or bioassay development. Folic acid has high affinity towards folate receptor, a cell membrane receptor that can be used for targeted drug delivery.
Physical Properties:
Yellow solid or viscous liquid depends on molecule weight;
Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Myristic acid is a 14 carbon saturated fatty acid lipid with excellent hydrophobicity. PEG modified myristic acid (PEG-myristic acid) is an excellent amphilphilic polymer with both hydrophilicity and hydrophobility. Pegylated lipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.
Physical Properties:
Off-white/white solid or viscous liquid depends on molecule weight;
Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Myristic acid is a 14 carbon saturated fatty acid lipid with excellent hydrophobicity. PEG modified myristic acid (PEG-myristic acid) is an excellent amphilphilic polymer with both hydrophilicity and hydrophobility. Pegylated lipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.
Physical Properties:
Off-white/white solid or viscous liquid depends on molecule weight;
Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Myristic acid is a 14 carbon saturated fatty acid lipid with excellent hydrophobicity. PEG modified myristic acid (PEG-myristic acid) is an excellent amphilphilic polymer with both hydrophilicity and hydrophobility. Pegylated lipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.
Physical Properties:
Off-white/white solid or viscous liquid depends on molecule weight;
Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Myristic acid is a 14 carbon saturated fatty acid lipid with excellent hydrophobicity. PEG modified myristic acid (PEG-myristic acid) is an excellent amphilphilic polymer with both hydrophilicity and hydrophobility. Pegylated lipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.
Physical Properties:
Off-white/white solid or viscous liquid depends on molecule weight;
Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Myristic acid is a 14 carbon saturated fatty acid lipid with excellent hydrophobicity. PEG modified myristic acid (PEG-myristic acid) is an excellent amphilphilic polymer with both hydrophilicity and hydrophobility. Pegylated lipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.
Physical Properties:
Off-white/white solid or viscous liquid depends on molecule weight;
Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Myristic acid is a 14 carbon saturated fatty acid lipid with excellent hydrophobicity. PEG modified myristic acid (PEG-myristic acid) is an excellent amphilphilic polymer with both hydrophilicity and hydrophobility. Pegylated lipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.
Physical Properties:
Off-white/white solid or viscous liquid depends on molecule weight;
Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Ursolic acid, a naturally occurring triterpenoid, induces the apoptosis of human cancer cells through multiple signaling pathways. In vitro: Ursolic acid is important in the induction of apoptosis via AKT/NF-κB signaling suppression in T24 human bladder cancer cells and this occurs in a dose-dependent manner. Thus, Akt and NF-κB are potential targets for bladder cancer therapy and ursolic acid may serve as a naturally-occurring candidate drug for the prevention and treatment of bladder cancer.[1] Ursolic acid induce apoptosis via inhibition of NF-κB induced BCl-2 mediated anti-apoptotic pathway leading to activation of p53 induced and caspase-3 mediated pro-apoptotic pathways.[2] In vivo: UA significantly suppressed prostate tumor growth in nude mice without any significant decrease in body weight. The systemic bioavailability of UA in serum samples obtained from nude mice. UA was detected in all serum samples 24 h after last injection. Systemic bioavailability of UA was in nanogram range and metabolites of UA were not detected in the samples. These results indicate that UA is well absorbed in the mouse peritoneum and supports the role of UA as a potent compound for chemoprevention and therapy of prostate cancer. [3]
IC50 & Target
Human Endogenous Metabolite
分子量
454.68
Formula
C30H46O3
CAS 号
6246-46-4
中文名称
熊果酮酸
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
溶解性数据
In Vitro:
DMSO : 50 mg/mL (109.97 mM; ultrasonic and warming and heat to 80°C)
H2O : 1 mg/mL (2.20 mM; ultrasonic and warming and heat to 80°C)
[1]. Gai, L., Cai, N., Wang, L., Xu, X. & Kong, X. Ursolic acid induces apoptosis via Akt/NF-kappaB signaling suppression in T24 human bladder cancer cells. Molecular medicine reports 7, 1673-1677, doi:10.3892/mmr.2013.1364 (2013).
[2]. Manu, K. A. & Kuttan, G. Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells. International immunopharmacology 8, 974-981, doi:10.1016/j.intimp.2008.02.013 (2008).
[3]. Shanmugam, M. K. et al. Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. Journal of molecular medicine 89, 713-727, doi:10.1007/s00109-011-0746-2 (2011).
![Conantokin G (free acid) 编码 [133628-78-1]](http://www.fluoroprobe.com/wp-content/uploads/2022/10/20221013_634870b059c9a.png)
![Conantokin G (free acid) 编码 [133628-78-1]](http://www.fluoroprobe.com/wp-content/uploads/2022/10/20221013_634870b0b0fa9.jpg)
![Conantokin G (free acid) 编码 [133628-78-1]](http://www.fluoroprobe.com/wp-content/uploads/2022/10/20221013_634870a77bd72.png)
![Conantokin G (free acid) 编码 [133628-78-1]](http://www.fluoroprobe.com/wp-content/uploads/2022/10/20221013_634870a7d4c0c.jpg)
