YAP-TEAD-IN-1 TFA

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YAP-TEAD-IN-1 TFA  纯度: 99.88%

YAP-TEAD-IN-1 TFA 是 YAP-TEAD 相互作用的有效的竞争性肽类抑制剂 (IC50=25 nM)。YAP-TEAD-IN-1 TFA 是一种 17mer 的多肽，与 YAP (50-171) (Kd=40 nM) 相比，其与 TEAD1 的结合亲和力更高 (Kd= 15 nM)。

YAP-TEAD-IN-1 TFA

YAP-TEAD-IN-1 TFA Chemical Structure

CAS No. : 1659305-79-9

规格 价格 是否有货 数量
1 mg ￥1800 In-stock
5 mg ￥4200 In-stock
10 mg ￥7000 In-stock
50 mg   询价  
100 mg   询价  

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YAP-TEAD-IN-1 TFA 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Macrocyclic Compound Library
  • Peptide Library

生物活性

YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM)[1].

IC50 & Target

IC50: 25 nM (YAP-TEAD interaction)[1]
体外研究
(In Vitro)

YAP-TEAD-IN-1 (peptide 17)(2 μM) is against endogenous YAP binding to GST-TEAD(1209-426) in a GST pull-down assay, the Kd of His-YAP(1209-426) is determined to be 40 nM[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Formula

C93H144ClN23O21S2.xC2HF3O2
CAS 号

1659305-79-9
Sequence

Ac-Val-Pro-{Phe(3-Cl)}-{Hcy}-Leu-Arg-Lys-{Nle}-Pro-Ala-Ser-Phe-Cys-Lys-Pro-Pro-Glu-NH2 (Disulfide bridge:Hcy4-Cys13)
Sequence Shortening

Ac-VP-{Phe(3-Cl)}-{Hcy}-LRK-{Nle}-PASFCKPPE-NH2 (Disulfide bridge:Hcy4-Cys13)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : ≥ 50 mg/mL

* “≥” means soluble, but saturation unknown.
参考文献

  • [1]. Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett. 2014 Jul 14;5(9):993-8.

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