Nortriptyline-d3 hydrochloride(Synonyms: Desmethylamitriptyline-d3 hydrochloride; Desitriptilina-d3 hydrochloride)

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Nortriptyline-d3 hydrochloride (Synonyms: Desmethylamitriptyline-d3 hydrochloride; Desitriptilina-d3 hydrochloride)

Nortriptyline-d3 (Desmethylamitriptyline-d3) hydrochloride 是 Nortriptyline hydrochloride 的氘代物。Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) 是三环类抗抑郁药,是 Amitriptyline 的主要活性代谢物,用于缓解抑郁症状。

Nortriptyline-d3 hydrochloride(Synonyms: Desmethylamitriptyline-d3 hydrochloride; Desitriptilina-d3 hydrochloride)

Nortriptyline-d3 hydrochloride Chemical Structure

CAS No. : 203784-52-5

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生物活性

Nortriptyline-d3 (Desmethylamitriptyline-d3) hydrochloride is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

302.86

Formula

C19H19D3ClN

CAS 号

203784-52-5

中文名称

盐酸去甲替林 d3 (盐酸盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.

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