Ivacaftor-d9(Synonyms: VX-770-d9)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ivacaftor-d9 (Synonyms: VX-770-d9)

Ivacaftor-D9 (CTP-656) 是一种有效的 CFTR 调节剂,在 G551D/F508del HBE 细胞中 CFTR 增强的 EC50 值为 255 nM。Ivacaftor- d9 作为一种具有口服活性和改良的 Ivacaftor 氘化物用于囊性纤维化研究。

Ivacaftor-d9(Synonyms: VX-770-d9)

Ivacaftor-d9 Chemical Structure

CAS No. : 1413431-07-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Ivacaftor-D9 (CTP-656) is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].

体内研究
(In Vivo)

In PK study, CTP-656 (oral gavage; 10 mg/kg; single dose) shows a superior pharmacokinetic profile, The plasma levels of compound were measured over 72 hours,exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 1970 ng/ml (15%), 24,260 hr*ng/ml(17%), 413 ng/ml (19%) and 13.9 hours, respectively in Male Sprague-Dawley rats.
CTP-656 (oral gavage; 3 mg/kg; single dose) exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 3643 ng/ml (9%), 49,782 hr*ng/ml(31%), 1418 ng/ml (31%) and 22.8 hours, respectively in Male Beagle Dogs (3.0 mg/kg).

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

401.55

Formula

C24H19D9N2O3

CAS 号

1413431-07-8

中文名称

依伐卡托 D9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367.

    [2]. Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Ivacaftor-d9(Synonyms: VX-770-d9)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ivacaftor-d9 (Synonyms: VX-770-d9)

Ivacaftor-D9 (CTP-656) 是一种有效的 CFTR 调节剂,在 G551D/F508del HBE 细胞中 CFTR 增强的 EC50 值为 255 nM。Ivacaftor- d9 作为一种具有口服活性和改良的 Ivacaftor 氘化物用于囊性纤维化研究。

Ivacaftor-d9(Synonyms: VX-770-d9)

Ivacaftor-d9 Chemical Structure

CAS No. : 1413431-07-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Ivacaftor-D9 (CTP-656) is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].

体内研究
(In Vivo)

In PK study, CTP-656 (oral gavage; 10 mg/kg; single dose) shows a superior pharmacokinetic profile, The plasma levels of compound were measured over 72 hours,exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 1970 ng/ml (15%), 24,260 hr*ng/ml(17%), 413 ng/ml (19%) and 13.9 hours, respectively in Male Sprague-Dawley rats.
CTP-656 (oral gavage; 3 mg/kg; single dose) exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 3643 ng/ml (9%), 49,782 hr*ng/ml(31%), 1418 ng/ml (31%) and 22.8 hours, respectively in Male Beagle Dogs (3.0 mg/kg).

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

401.55

Formula

C24H19D9N2O3

CAS 号

1413431-07-8

中文名称

依伐卡托 D9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367.

    [2]. Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Ivacaftor-d9(Synonyms: VX-770-d9)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ivacaftor-d9 (Synonyms: VX-770-d9)

Ivacaftor-D9 (CTP-656) 是一种有效的 CFTR 调节剂,在 G551D/F508del HBE 细胞中 CFTR 增强的 EC50 值为 255 nM。Ivacaftor- d9 作为一种具有口服活性和改良的 Ivacaftor 氘化物用于囊性纤维化研究。

Ivacaftor-d9(Synonyms: VX-770-d9)

Ivacaftor-d9 Chemical Structure

CAS No. : 1413431-07-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Ivacaftor-D9 (CTP-656) is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].

体内研究
(In Vivo)

In PK study, CTP-656 (oral gavage; 10 mg/kg; single dose) shows a superior pharmacokinetic profile, The plasma levels of compound were measured over 72 hours,exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 1970 ng/ml (15%), 24,260 hr*ng/ml(17%), 413 ng/ml (19%) and 13.9 hours, respectively in Male Sprague-Dawley rats.
CTP-656 (oral gavage; 3 mg/kg; single dose) exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 3643 ng/ml (9%), 49,782 hr*ng/ml(31%), 1418 ng/ml (31%) and 22.8 hours, respectively in Male Beagle Dogs (3.0 mg/kg).

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

401.55

Formula

C24H19D9N2O3

CAS 号

1413431-07-8

中文名称

依伐卡托 D9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367.

    [2]. Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Olaparib-d8(Synonyms: AZD2281-d8; KU0059436-d8)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Olaparib-d8 (Synonyms: AZD2281-d8; KU0059436-d8)

Olaparib D8 (AZD2281 D8) 是 Olaparib (AZD2281) 的氘代物。Olaparib 是一种口服有效的 PARP 抑制剂,抑制 PARP-1PARP-2IC50 分别为 5 和 1 nM。Olaparib 是一种自噬 (autophagy) 和线粒体自噬 (mitophagy) 激活剂。

Olaparib-d8(Synonyms: AZD2281-d8;  KU0059436-d8)

Olaparib-d8 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Olaparib D8 (AZD2281 D8) is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

分子量

442.51

Formula

C24H15D8FN4O3

中文名称

奥拉帕尼 d8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Menear KA, et al. 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. J Med Chem. 2008 Oct 23;51(20):6581-91

    [2]. Senra JM, et al. Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.Mol Cancer Ther. 2011 Oct;10(10):1949-58.

    [3]. Yasukawa M, et al. Synergetic Effects of PARP Inhibitor AZD2281 in Oral Squamous Cell Carcinoma in Vitro and in Vivo. Int J Mol Sci. 2016 Feb 24;17(3):272.

    [4]. Bian X, et al. PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy. Oncogene. 2018 Jan 18;37(3):341-351.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Olaparib-d8(Synonyms: AZD2281-d8; KU0059436-d8)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Olaparib-d8 (Synonyms: AZD2281-d8; KU0059436-d8)

Olaparib D8 (AZD2281 D8) 是 Olaparib (AZD2281) 的氘代物。Olaparib 是一种口服有效的 PARP 抑制剂,抑制 PARP-1PARP-2IC50 分别为 5 和 1 nM。Olaparib 是一种自噬 (autophagy) 和线粒体自噬 (mitophagy) 激活剂。

Olaparib-d8(Synonyms: AZD2281-d8;  KU0059436-d8)

Olaparib-d8 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Olaparib D8 (AZD2281 D8) is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

分子量

442.51

Formula

C24H15D8FN4O3

中文名称

奥拉帕尼 d8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Menear KA, et al. 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. J Med Chem. 2008 Oct 23;51(20):6581-91

    [2]. Senra JM, et al. Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.Mol Cancer Ther. 2011 Oct;10(10):1949-58.

    [3]. Yasukawa M, et al. Synergetic Effects of PARP Inhibitor AZD2281 in Oral Squamous Cell Carcinoma in Vitro and in Vivo. Int J Mol Sci. 2016 Feb 24;17(3):272.

    [4]. Bian X, et al. PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy. Oncogene. 2018 Jan 18;37(3):341-351.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Olaparib-d8(Synonyms: AZD2281-d8; KU0059436-d8)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Olaparib-d8 (Synonyms: AZD2281-d8; KU0059436-d8)

Olaparib D8 (AZD2281 D8) 是 Olaparib (AZD2281) 的氘代物。Olaparib 是一种口服有效的 PARP 抑制剂,抑制 PARP-1PARP-2IC50 分别为 5 和 1 nM。Olaparib 是一种自噬 (autophagy) 和线粒体自噬 (mitophagy) 激活剂。

Olaparib-d8(Synonyms: AZD2281-d8;  KU0059436-d8)

Olaparib-d8 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Olaparib D8 (AZD2281 D8) is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

分子量

442.51

Formula

C24H15D8FN4O3

中文名称

奥拉帕尼 d8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Menear KA, et al. 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. J Med Chem. 2008 Oct 23;51(20):6581-91

    [2]. Senra JM, et al. Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.Mol Cancer Ther. 2011 Oct;10(10):1949-58.

    [3]. Yasukawa M, et al. Synergetic Effects of PARP Inhibitor AZD2281 in Oral Squamous Cell Carcinoma in Vitro and in Vivo. Int J Mol Sci. 2016 Feb 24;17(3):272.

    [4]. Bian X, et al. PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy. Oncogene. 2018 Jan 18;37(3):341-351.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

(Rac)-Ruxolitinib-d9(Synonyms: (Rac)-INCB18424-d9)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

(Rac)-Ruxolitinib-d9 (Synonyms: (Rac)-INCB18424-d9)

(Rac)-Ruxolitinib D9 ((Rac)-INCB18424 D9) 是氘代的 (Rac)-Ruxolitinib。(Rac)-Ruxolitinib 是 JAK2 抑制剂。

(Rac)-Ruxolitinib-d9(Synonyms: (Rac)-INCB18424-d9)

(Rac)-Ruxolitinib-d9 Chemical Structure

CAS No. : 2469553-67-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

(Rac)-Ruxolitinib D9 ((Rac)-INCB18424 D9) is the deuterium labeled (Rac)-Ruxolitinib. (Rac)-Ruxolitinib is a JAK2 inhibitor[1].

体内研究
(In Vivo)

(Rac)-Ruxolitinib氘代物

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

315.42

Formula

C17H9D9N6

CAS 号

2469553-67-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yaoyu CHEN, et al. Combination therapy comprising an alk2 inhibitor and a jak2 inhibitor. Patent WO2021102258A1

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

(Rac)-Ruxolitinib-d9(Synonyms: (Rac)-INCB18424-d9)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

(Rac)-Ruxolitinib-d9 (Synonyms: (Rac)-INCB18424-d9)

(Rac)-Ruxolitinib D9 ((Rac)-INCB18424 D9) 是氘代的 (Rac)-Ruxolitinib。(Rac)-Ruxolitinib 是 JAK2 抑制剂。

(Rac)-Ruxolitinib-d9(Synonyms: (Rac)-INCB18424-d9)

(Rac)-Ruxolitinib-d9 Chemical Structure

CAS No. : 2469553-67-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

(Rac)-Ruxolitinib D9 ((Rac)-INCB18424 D9) is the deuterium labeled (Rac)-Ruxolitinib. (Rac)-Ruxolitinib is a JAK2 inhibitor[1].

体内研究
(In Vivo)

(Rac)-Ruxolitinib氘代物

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

315.42

Formula

C17H9D9N6

CAS 号

2469553-67-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yaoyu CHEN, et al. Combination therapy comprising an alk2 inhibitor and a jak2 inhibitor. Patent WO2021102258A1

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

(Rac)-Ruxolitinib-d9(Synonyms: (Rac)-INCB18424-d9)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

(Rac)-Ruxolitinib-d9 (Synonyms: (Rac)-INCB18424-d9)

(Rac)-Ruxolitinib D9 ((Rac)-INCB18424 D9) 是氘代的 (Rac)-Ruxolitinib。(Rac)-Ruxolitinib 是 JAK2 抑制剂。

(Rac)-Ruxolitinib-d9(Synonyms: (Rac)-INCB18424-d9)

(Rac)-Ruxolitinib-d9 Chemical Structure

CAS No. : 2469553-67-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

(Rac)-Ruxolitinib D9 ((Rac)-INCB18424 D9) is the deuterium labeled (Rac)-Ruxolitinib. (Rac)-Ruxolitinib is a JAK2 inhibitor[1].

体内研究
(In Vivo)

(Rac)-Ruxolitinib氘代物

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

315.42

Formula

C17H9D9N6

CAS 号

2469553-67-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yaoyu CHEN, et al. Combination therapy comprising an alk2 inhibitor and a jak2 inhibitor. Patent WO2021102258A1

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

S-Adenosyl-L-methionine-d3(Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

S-Adenosyl-L-methionine-d3 (Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

S-Adenosyl-L-methionine D3 (S-Adenosyl methionine D3) 是S-Adenosyl-L-methionine 的氘代物。S-Adenosyl-L-methionine 是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的,是一种重要的具有口服活性的甲基供体。

S-Adenosyl-L-methionine-d3(Synonyms: S-Adenosyl methionine-d3;  Ademetionine-d3;  AdoMet-d3)

S-Adenosyl-L-methionine-d3 Chemical Structure

CAS No. : 68684-40-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

S-Adenosyl-L-methionine D3 (S-Adenosyl methionine D3) is a deuterium labeled S-Adenosyl-L-methionine. S-Adenosyl-L-methionine is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor[1][2].

分子量

401.46

Formula

C15H19D3N6O5S

CAS 号

68684-40-2

中文名称

S-腺苷-L-蛋氨酸D3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.

    [2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6.

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S-Adenosyl-L-methionine-d3(Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

S-Adenosyl-L-methionine-d3 (Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

S-Adenosyl-L-methionine D3 (S-Adenosyl methionine D3) 是S-Adenosyl-L-methionine 的氘代物。S-Adenosyl-L-methionine 是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的,是一种重要的具有口服活性的甲基供体。

S-Adenosyl-L-methionine-d3(Synonyms: S-Adenosyl methionine-d3;  Ademetionine-d3;  AdoMet-d3)

S-Adenosyl-L-methionine-d3 Chemical Structure

CAS No. : 68684-40-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

S-Adenosyl-L-methionine D3 (S-Adenosyl methionine D3) is a deuterium labeled S-Adenosyl-L-methionine. S-Adenosyl-L-methionine is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor[1][2].

分子量

401.46

Formula

C15H19D3N6O5S

CAS 号

68684-40-2

中文名称

S-腺苷-L-蛋氨酸D3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.

    [2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6.

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S-Adenosyl-L-methionine-d3(Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

S-Adenosyl-L-methionine-d3 (Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

S-Adenosyl-L-methionine D3 (S-Adenosyl methionine D3) 是S-Adenosyl-L-methionine 的氘代物。S-Adenosyl-L-methionine 是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的,是一种重要的具有口服活性的甲基供体。

S-Adenosyl-L-methionine-d3(Synonyms: S-Adenosyl methionine-d3;  Ademetionine-d3;  AdoMet-d3)

S-Adenosyl-L-methionine-d3 Chemical Structure

CAS No. : 68684-40-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

S-Adenosyl-L-methionine D3 (S-Adenosyl methionine D3) is a deuterium labeled S-Adenosyl-L-methionine. S-Adenosyl-L-methionine is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor[1][2].

分子量

401.46

Formula

C15H19D3N6O5S

CAS 号

68684-40-2

中文名称

S-腺苷-L-蛋氨酸D3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.

    [2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Zanubrutinib D5(Synonyms: BGB-3111 D5)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Zanubrutinib D5 (Synonyms: BGB-3111 D5)

Zanubrutinib D5 (BGB-3111 D5) 是 Zanubrutinib 的氘代物。Zanubrutinib 是一种选择性的 Bruton tyrosine kinase (Btk) 抑制剂。

Zanubrutinib D5(Synonyms: BGB-3111 D5)

Zanubrutinib D5 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Zanubrutinib D5 (BGB-3111 D5) is deuterium labeled Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (Btk) inhibitor[1].

分子量

476.58

Formula

C27H24D5N5O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Na Li, et al. Abstract 2597: BGB-3111 is a novel and highly selective Bruton’s tyrosine kinase (BTK) inhibitor. Cancer Res 2015;75(15 Suppl):Abstract nr 2597.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Zanubrutinib D5(Synonyms: BGB-3111 D5)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Zanubrutinib D5 (Synonyms: BGB-3111 D5)

Zanubrutinib D5 (BGB-3111 D5) 是 Zanubrutinib 的氘代物。Zanubrutinib 是一种选择性的 Bruton tyrosine kinase (Btk) 抑制剂。

Zanubrutinib D5(Synonyms: BGB-3111 D5)

Zanubrutinib D5 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Zanubrutinib D5 (BGB-3111 D5) is deuterium labeled Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (Btk) inhibitor[1].

分子量

476.58

Formula

C27H24D5N5O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Na Li, et al. Abstract 2597: BGB-3111 is a novel and highly selective Bruton’s tyrosine kinase (BTK) inhibitor. Cancer Res 2015;75(15 Suppl):Abstract nr 2597.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Paclitaxel-d5(Synonyms: 紫杉醇 d5)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Paclitaxel-d5 (Synonyms: 紫杉醇 d5)

Paclitaxel-d5 是氘标记的紫杉醇。Paclitaxel 是一种天然抗肿瘤药,可稳定微管蛋白 (tubulin) 的聚合。

Paclitaxel-d5(Synonyms: 紫杉醇 d5)

Paclitaxel-d5 Chemical Structure

CAS No. : 1129540-33-5

规格 价格 是否有货
1 mg ¥14500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Paclitaxel-d5 is a deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization[1].

分子量

858.94

Formula

C47H46D5NO14

CAS 号

1129540-33-5

中文名称

紫杉醇 d5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Choi YH, et al. Paclitaxel-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. Oncol Rep. 2012 Dec;28(6):2163-9.

    [2]. Dziadyk JM, et al. Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest. Anticancer Res. 2004 Jan-Feb;24(1):27-36.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Zanubrutinib D5(Synonyms: BGB-3111 D5)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Zanubrutinib D5 (Synonyms: BGB-3111 D5)

Zanubrutinib D5 (BGB-3111 D5) 是 Zanubrutinib 的氘代物。Zanubrutinib 是一种选择性的 Bruton tyrosine kinase (Btk) 抑制剂。

Zanubrutinib D5(Synonyms: BGB-3111 D5)

Zanubrutinib D5 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Zanubrutinib D5 (BGB-3111 D5) is deuterium labeled Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (Btk) inhibitor[1].

分子量

476.58

Formula

C27H24D5N5O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Na Li, et al. Abstract 2597: BGB-3111 is a novel and highly selective Bruton’s tyrosine kinase (BTK) inhibitor. Cancer Res 2015;75(15 Suppl):Abstract nr 2597.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Paclitaxel-d5(Synonyms: 紫杉醇 d5)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Paclitaxel-d5 (Synonyms: 紫杉醇 d5)

Paclitaxel-d5 是氘标记的紫杉醇。Paclitaxel 是一种天然抗肿瘤药,可稳定微管蛋白 (tubulin) 的聚合。

Paclitaxel-d5(Synonyms: 紫杉醇 d5)

Paclitaxel-d5 Chemical Structure

CAS No. : 1129540-33-5

规格 价格 是否有货
1 mg ¥14500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Paclitaxel-d5 is a deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization[1].

分子量

858.94

Formula

C47H46D5NO14

CAS 号

1129540-33-5

中文名称

紫杉醇 d5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Choi YH, et al. Paclitaxel-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. Oncol Rep. 2012 Dec;28(6):2163-9.

    [2]. Dziadyk JM, et al. Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest. Anticancer Res. 2004 Jan-Feb;24(1):27-36.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Paclitaxel-d5(Synonyms: 紫杉醇 d5)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Paclitaxel-d5 (Synonyms: 紫杉醇 d5)

Paclitaxel-d5 是氘标记的紫杉醇。Paclitaxel 是一种天然抗肿瘤药,可稳定微管蛋白 (tubulin) 的聚合。

Paclitaxel-d5(Synonyms: 紫杉醇 d5)

Paclitaxel-d5 Chemical Structure

CAS No. : 1129540-33-5

规格 价格 是否有货
1 mg ¥14500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Paclitaxel-d5 is a deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization[1].

分子量

858.94

Formula

C47H46D5NO14

CAS 号

1129540-33-5

中文名称

紫杉醇 d5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Choi YH, et al. Paclitaxel-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. Oncol Rep. 2012 Dec;28(6):2163-9.

    [2]. Dziadyk JM, et al. Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest. Anticancer Res. 2004 Jan-Feb;24(1):27-36.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Lurbinectedin-d3(Synonyms: PM01183-d3)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Lurbinectedin-d3 (Synonyms: PM01183-d3)

Lurbinectedin D3 是 Lurbinectedin 的氘代物。Lurbinectedin (PM01183) 是一种 DNA 小沟共价粘合剂,具有高效的抗肿瘤活性; 抑制 RMG1 和 RMG2 的 IC50 值分别为 1.25 和 1.16 nM。

Lurbinectedin-d3(Synonyms: PM01183-d3)

Lurbinectedin-d3 Chemical Structure

规格 价格 是否有货 数量
100 μg ¥6800 In-stock
500 μg ¥15000 In-stock
1 mg ¥24000 In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

生物活性

Lurbinectedin D3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively[1].

分子量

787.89

Formula

C41H41D3N4O10S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献
  • [1]. Takahashi R, et al. Preclinical Investigations of PM01183 (Lurbinectedin) as a Single Agent or in Combination with Other Anticancer Agents for Clear Cell Carcinoma of the Ovary. PLoS One. 2016 Mar 17;11(3):e0151050.

    [2]. Leal JF, et al. PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Br J Pharmacol. 2010 Nov;161(5):1099-110.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Lurbinectedin-d3(Synonyms: PM01183-d3)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Lurbinectedin-d3 (Synonyms: PM01183-d3)

Lurbinectedin D3 是 Lurbinectedin 的氘代物。Lurbinectedin (PM01183) 是一种 DNA 小沟共价粘合剂,具有高效的抗肿瘤活性; 抑制 RMG1 和 RMG2 的 IC50 值分别为 1.25 和 1.16 nM。

Lurbinectedin-d3(Synonyms: PM01183-d3)

Lurbinectedin-d3 Chemical Structure

规格 价格 是否有货 数量
100 μg ¥6800 In-stock
500 μg ¥15000 In-stock
1 mg ¥24000 In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

生物活性

Lurbinectedin D3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively[1].

分子量

787.89

Formula

C41H41D3N4O10S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献
  • [1]. Takahashi R, et al. Preclinical Investigations of PM01183 (Lurbinectedin) as a Single Agent or in Combination with Other Anticancer Agents for Clear Cell Carcinoma of the Ovary. PLoS One. 2016 Mar 17;11(3):e0151050.

    [2]. Leal JF, et al. PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Br J Pharmacol. 2010 Nov;161(5):1099-110.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务