Amifostine(Synonyms: 氨磷汀; WR2721)

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Amifostine (Synonyms: 氨磷汀; WR2721) 纯度: ≥98.0%

Amifostine (WR2721) 是一种广谱细胞保护剂和辐射防护剂。Amifostine 可选择性保护正常组织免受放射线和化学疗法造成的损害。Amifostine 是有效的 HIF-α1 和 p53 诱导剂。Amifostine 通过清除氧衍生的自由基来保护细胞免受损伤。Amifostine 可降低肾脏毒性并具有抗血管生成作用。

Amifostine(Synonyms: 氨磷汀; WR2721)

Amifostine Chemical Structure

CAS No. : 20537-88-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in Water ￥552 In-stock
10 mg ￥502 In-stock
50 mg ￥2111 In-stock
100 mg ￥3550 In-stock
200 mg ￥5680 In-stock
500 mg   询价  
1 g   询价  

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生物活性

Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action[1][2][3][4].

Clinical Trial

分子量

214.22

Formula

C5H15N2O3PS
CAS 号

20537-88-6
中文名称

氨磷汀；安磷汀；阿米福汀
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 100 mg/mL (466.81 mM; Need ultrasonic)

DMF : 1 mg/mL (4.67 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.6681 mL 23.3405 mL 46.6810 mL
5 mM 0.9336 mL 4.6681 mL 9.3362 mL
10 mM 0.4668 mL 2.3340 mL 4.6681 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kouvaris, J.R., V.E. Kouloulias, and L.J. Vlahos, Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist, 2007. 12(6): p. 738-47.

    [2]. D Maurici, et al. Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene. 2001 Jun 14;20(27):3533-40.

    [3]. Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304(2):729-37.

    [4]. Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53(1):8-14.

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