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Formononetin (Synonyms: 刺芒柄花素; Biochanin B; Flavosil; Formononetol) 纯度: 99.88%
Formononetin 是一种有效的 FGFR2 抑制剂,IC50 为 ~4.31 μM。 Formononetin 有效抑制血管生成和肿瘤生长。
Formononetin Chemical Structure
CAS No. : 485-72-3
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥500 | In-stock | |
10 mg | ¥450 | In-stock | |
50 mg | ¥900 | In-stock | |
100 mg | ¥1200 | In-stock | |
200 mg | ¥1650 | In-stock | |
500 mg | ¥2600 | In-stock | |
1 g | 询价 | ||
5 g | 询价 |
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生物活性 |
Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
Formononetin is one of the major isoflavonoid constituents isolated from Astragalus membranaceus and has been demonstrated diverse pharmacological benefits. Formononetin possesses anti-angiogenic activity in human colon cancer cells. Formononetin also promotes cell cycle arrest via downregulation of Akt/Cyclin D1/CDK4 in human prostate cancer cells[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
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体内研究 (In Vivo) |
Formononetin dramatically suppresses tumor volumes and the Formononetin-treated group tumor weight are significantly inhibited compared with the vehicle group . Formononetin treatment is well tolerated, and there is no significant difference in weight between vehicle group and formononetin treated groups[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
268.26 |
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Formula |
C16H12O4 |
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CAS 号 |
485-72-3 |
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中文名称 |
刺芒柄花素;生原禅宁 B;素普拉脑 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 35 mg/mL (130.47 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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