Ipilimumab(Synonyms: 伊匹木单抗; MDX-010; BMS-734016)

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Ipilimumab (Synonyms: 伊匹木单抗; MDX-010; BMS-734016) 纯度: 99.88%

Ipilimumab 是一种全人类单克隆抗体 IgG1κ,能够抗 CTLA-4(一种由活化的 T 细胞产生的免疫抑制分子)。

Ipilimumab(Synonyms: 伊匹木单抗; MDX-010;  BMS-734016)

Ipilimumab Chemical Structure

CAS No. : 477202-00-9

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生物活性

Ipilimumab is a fully human monoclonal IgG1κ antibody against the cytotoxic T-lymphocyte antigen-4 (CTLA-4), an immune-inhibitory molecule expressed in activated T cells and in suppressor T regulatory cells.

体外研究
(In Vitro)

Ipilimumab inhibits CTLA-4, allowing the T cell immune response to be reactivated against tumor cells. Ipilimumab can promote antitumor activity as a single agent or in combination with cytokines, chemotherapy, or vaccines[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

145313.36

CAS 号

477202-00-9

中文名称

易普利姆玛;伊匹单抗;伊匹木单抗

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Movva S, et al. The monoclonal antibody to cytotoxic T lymphocyte antigen 4, ipilimumab (MDX-010), a novel treatment strategy in cancer management. Expert Opin Biol Ther. 2009 Feb;9(2):231-41.

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