磷霉素钠盐
>95.0%
有货
基本信息
| 产品名称 | 磷霉素钠盐 |
|---|---|
| 英文名称 | Fosmidomycin sodium salt |
| 别名 | 膦胺霉素钠盐 |
| 英文别名 | P-[3-(formylhydroxyamino)propyl]-phosphonic acid, monosodium salt;FR-31564;Antibiotic FR31564;FR31564 |
| 规格或纯度 | >95.0% |
| 运输条件 | 超低温冰袋运输 |
一般描述
Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial drug, which is active against both Gram-negative and Gram-positive bacteria.
Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP). Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces.
1-deoxy-d-xylulose 5-phosphate reductoisomerase is an enzyme that interconverts DXP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Fosmidomycin was active against both Gram-negative and Gram-positive bacteria and the human malarial parasite P. falciparum with the IC50 of 290-370 nM. Fosmidomycin inhibited 1-deoxy-d-xylulose 5-phosphate reductoisomerase in an alternative nonmevalonate pathway for terpenoid biosynthesis with IC50 of 8.2 nM. Fosmidomycin has been shown to possess activity against Plasmodium falciparum in vitro and in the mouse model. In patients with acute uncomplicated Plasmodium falciparum malaria, oral administration of 1,200 mg fosmidomycin every 8 h for 7 days was effective in curing uncomplicated Plasmodiumfalciparum malaria in humans. Fosmidomycin was an effective and safe antimalarial drug. The treatment was well tolerated and showed a fast parasite and fever clearance.
Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial drug, which is active against both Gram-negative and Gram-positive bacteria.
Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP). Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces.
1-deoxy-d-xylulose 5-phosphate reductoisomerase is an enzyme that interconverts DXP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Fosmidomycin was active against both Gram-negative and Gram-positive bacteria and the human malarial parasite P. falciparum with the IC50 of 290-370 nM. Fosmidomycin inhibited 1-deoxy-d-xylulose 5-phosphate reductoisomerase in an alternative nonmevalonate pathway for terpenoid biosynthesis with IC50 of 8.2 nM. Fosmidomycin has been shown to possess activity against Plasmodium falciparum in vitro and in the mouse model. In patients with acute uncomplicated Plasmodium falciparum malaria, oral administration of 1,200 mg fosmidomycin every 8 h for 7 days was effective in curing uncomplicated Plasmodiumfalciparum malaria in humans. Fosmidomycin was an effective and safe antimalarial drug. The treatment was well tolerated and showed a fast parasite and fever clearance.
相关属性
| CAS编号 | 66508-37-0 |
|---|---|
| 溶解性 | ≤5mg/ml in PBS, pH 7.2 |
| 储存温度 | -20°C储存,充氩 |
| 分子量 | 205.08 |
| 分子式 | C4H9NNaO5P |
| 品牌 | Jinpan |
| PubChem CID | 5141362 |