茉莉花内酯
肌动蛋白聚合和稳定诱导剂。细胞可渗透的。
≥97% (HPLC)
有货
基本信息
| 产品名称 | 茉莉花内酯 |
|---|---|
| 英文名称 | Jasplakinolide |
| 别名 | Jaspamide |
| 英文别名 | NSC 613009; cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-8S-hydroxy-2S,4E,6R-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl] |
| 规格或纯度 | ≥97% (HPLC) |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments. In vitro, Jasplakinolidet potently induces actin polymerization by stimulating actin filament nucleation and competes with phalloidin for actin binding (Kd = 15 nM). In vivo, Jasplakinolide has been found to disrupt actin filaments and induce polymerization of monomeric actin into amorphous masses, the exact mechanism of which has not been determined yet. Jasplakinolide differs from other actin stabilizers in that it is cell permeable. This peptide has fungicidal, insecticidal and antiproliferative activity, and is useful for investigating cell processes mediated by actin polymerization and depolymerization, such as cell adhesion, locomotion, endocytosis, and vesicle sorting and release.Cell-permeable actin polymerization and stabilization inducer. Potent antiproliferative activity (IC 50 = 15 nM). Antitumor and antifungal agent. Active in vitro . |
一般描述
A cell permeable compound which stabilizes pre-formed actin filaments and inhibits their disassembly.
A cell permeable compound which stabilizes pre-formed actin filaments and inhibits their disassembly.
相关属性
| CAS编号 | 102396-24-7 |
|---|---|
| 敏感性 | 对光敏感 |
| 溶解性 | Soluble in DMSO (>2 mg/ml), water (partly), 100% ethanol, and 83% methanol |
| 储存温度 | 避光,-20°C储存 |
| RTECS | GX7000000 |
| MDL号 | MFCD00873735 |
| 分子量 | 709.67 |
| 分子式 | C36H45BrN4O6 |
| 品牌 | Jinpan |
| 备注 | 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| PubChem CID | 134689754 |