Novobiocin Sodium(Synonyms: Albamycin; Cathomycin)

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Novobiocin Sodium (Synonyms: Albamycin; Cathomycin) 纯度: 95.32%

Novobiocin Sodium (Albamycin; Cathomycin) 是一种口服抗生素 (antibiotic) 化合物，源于链霉菌，也是一个强效的 DNA gyrase 抑制剂通过结合 ATP 结合位点在 ATP 酶亚基。Novobiocin Sodium 对革兰氏阳性菌有较强的抗菌活性，但由于外膜中含有脂多糖，对革兰氏阴性菌的抗菌活性有限。Novobiocin Sodium 与 Hsp90 的 c 端结合，轻微诱导 Hsp90 依赖的 client 蛋白的降解 (IC50=700 μM)。

Novobiocin Sodium(Synonyms: Albamycin; Cathomycin)

Novobiocin Sodium Chemical Structure

CAS No. : 1476-53-5

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥990 In-stock
100 mg ￥900 In-stock
500 mg ￥2000 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

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生物活性

Novobiocin Sodium (Albamycin; Cathomycin) is an orally active antibiotic compound derived from Streptomyces niveus and a potent DNA gyrase inhibitor by binding the ATP-binding site in the ATPase subunit[1]. Novobiocin Sodium manifests strong anti-bacterial activities effectively against gram-positive pathogens and shows limited activity against gram-negative organisms due to LPS-containing outer membrane.Novobiocin Sodium binds to the C-terminus of Hsp90 and slightly induces degradation of Hsp90-dependent client proteins (IC50=700 µM)[1][2].

IC50 & Target

IC50: 700 μM (HSP90)[2]
体外研究
(In Vitro)

Novobiocin Sodium (0.3 mM; 48 hours) induces a caspase-3/7 enzyme–dependent apoptosis assays with an induction of approximately three- to fivefold of apoptotic cells in K562, HL60, Mutz-2[1].
Novobiocin (0-500 μM; 15-hours) is against wild type, lptB1, lptB1(R144H), and efflux pump-deficient ∆tolC strains with IC50 values of 62.5-125 μM; 0.5 μM; 62.5-125 μM; and 2 μM, respectively[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: K562, HL60, Mutz-2 cells
Concentration: 0.3 mM
Incubation Time: 48 hours
Result: Decreased caspase-3/7 activity in K562, HL60, Mutz-2 cells.

分子量

634.61

Formula

C31H35N2NaO11
CAS 号

1476-53-5
中文名称

新生霉素钠
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 250 mg/mL (393.94 mM; Need ultrasonic)

DMSO : ≥ 30 mg/mL (47.27 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5758 mL 7.8789 mL 15.7577 mL
5 mM 0.3152 mL 1.5758 mL 3.1515 mL
10 mM 0.1576 mL 0.7879 mL 1.5758 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Bhatia S, et al. Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.Blood. 2018 Jul 19;132(3):307-320.

    [2]. Burlison JA, et al. Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90.J Am Chem Soc. 2006 Dec 6;128(48):15529-36.

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