标签归档：novobiocin

Novobiocin Sodium(Synonyms: Albamycin; Cathomycin)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Novobiocin Sodium (Synonyms: Albamycin; Cathomycin) 纯度: 95.32%

Novobiocin Sodium (Albamycin; Cathomycin) 是一种口服抗生素 (antibiotic) 化合物，源于链霉菌，也是一个强效的 DNA gyrase 抑制剂通过结合 ATP 结合位点在 ATP 酶亚基。Novobiocin Sodium 对革兰氏阳性菌有较强的抗菌活性，但由于外膜中含有脂多糖，对革兰氏阴性菌的抗菌活性有限。Novobiocin Sodium 与 Hsp90 的 c 端结合，轻微诱导 Hsp90 依赖的 client 蛋白的降解 (IC50=700 μM)。

Novobiocin Sodium(Synonyms: Albamycin; Cathomycin)

Novobiocin Sodium Chemical Structure

CAS No. : 1476-53-5

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥990 In-stock
100 mg ￥900 In-stock
500 mg ￥2000 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

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生物活性

Novobiocin Sodium (Albamycin; Cathomycin) is an orally active antibiotic compound derived from Streptomyces niveus and a potent DNA gyrase inhibitor by binding the ATP-binding site in the ATPase subunit[1]. Novobiocin Sodium manifests strong anti-bacterial activities effectively against gram-positive pathogens and shows limited activity against gram-negative organisms due to LPS-containing outer membrane.Novobiocin Sodium binds to the C-terminus of Hsp90 and slightly induces degradation of Hsp90-dependent client proteins (IC50=700 µM)[1][2].

IC50 & Target

IC50: 700 μM (HSP90)[2]
体外研究
(In Vitro)

Novobiocin Sodium (0.3 mM; 48 hours) induces a caspase-3/7 enzyme–dependent apoptosis assays with an induction of approximately three- to fivefold of apoptotic cells in K562, HL60, Mutz-2[1].
Novobiocin (0-500 μM; 15-hours) is against wild type, lptB1, lptB1(R144H), and efflux pump-deficient ∆tolC strains with IC50 values of 62.5-125 μM; 0.5 μM; 62.5-125 μM; and 2 μM, respectively[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: K562, HL60, Mutz-2 cells
Concentration: 0.3 mM
Incubation Time: 48 hours
Result: Decreased caspase-3/7 activity in K562, HL60, Mutz-2 cells.

分子量

634.61

Formula

C31H35N2NaO11
CAS 号

1476-53-5
中文名称

新生霉素钠
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 250 mg/mL (393.94 mM; Need ultrasonic)

DMSO : ≥ 30 mg/mL (47.27 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5758 mL 7.8789 mL 15.7577 mL
5 mM 0.3152 mL 1.5758 mL 3.1515 mL
10 mM 0.1576 mL 0.7879 mL 1.5758 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Bhatia S, et al. Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.Blood. 2018 Jul 19;132(3):307-320.

    [2]. Burlison JA, et al. Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90.J Am Chem Soc. 2006 Dec 6;128(48):15529-36.

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Cas(1476-53-5), Novobiocin Sodium, 新生霉素钠,Novobiocin Sodium,

发表于由

新生霉素（钠盐）

抗生素。强大的竞争性DNA回旋酶抑制剂。
≥95%

有货

Cas(1476-53-5), Novobiocin Sodium, 新生霉素钠,Novobiocin Sodium,

CAS编号 1476-53-5 | 品牌：Jinpan
Novobiocin Sodium

MSDS

质检证书(CoA)

相似产品

  • 分子式 C31H35N2NaO11
  • 分子量634.61
  • Beilstein号 3892910
  • EC号 216-023-6
  • PubChem编号 54730021

货号 (SKU) 包装规格 是否现货 价格 数量
N129248-100mg 100mg 现货 Cas(1476-53-5), Novobiocin Sodium, 新生霉素钠,Novobiocin Sodium,  
N129248-250mg 250mg 现货 Cas(1476-53-5), Novobiocin Sodium, 新生霉素钠,Novobiocin Sodium,  
N129248-1g 1g 现货 Cas(1476-53-5), Novobiocin Sodium, 新生霉素钠,Novobiocin Sodium,  
N129248-5g 5g 现货 Cas(1476-53-5), Novobiocin Sodium, 新生霉素钠,Novobiocin Sodium,  

基本信息

产品名称 新生霉素（钠盐）
英文名称 Novobiocin Sodium
别名 新生霉素钠；N-[7-[[3-O- (氨基羰基)-6-脱氧-5-C-甲基-4-O-甲基-α-L-lyxo-吡喃己糖基]氧基]-4-羟基-8-甲基- 2-oxo-2H-1 -benzopyran-3- benzamide；单钠盐
英文别名 Albamycin; Cathomycin sodium;Albamycin sodium; Cathomycin sodium lyovac; Monosodium novobiocin; NSC 2382; Novobiocin monosodium
应用 An Hsp90 and DNA gyrase inhibitor.
规格或纯度 ≥95%
运输条件 超低温冰袋运输
生化机理 Novobiocin Sodium (U-6591) is a small molecule inhibitor of eukaryotic DNA topoisomerase II and prokaryotic DNA gyrase. In the case of DNA gyrase inhibition, Novobiocin functions as a competitive inhibitor of the ATP binding event necessary for turnover of the enzyme after a manipulation of DNA supercoils. Inhibition of these enzymes blocks the mechanism for detangling DNA and establishing the proper super-coiled state necessary for normal replication and transcription, compromising the viability of the cell. Treatment with Novobiocin is shown to potentiate the cytotoxic effects of DNA alkylating agents. Novobiocin is also described to inhibit the activity of retroviral RNA-dependent DNA polymerase. Novobiocin is an inhibitor of Hsp90. Novobiocin interacts with the C-terminal ATP-binding domain of Hsp90.Antibiotic. Potent, competitive DNA gyrase inhibitor (IC 50 = 80 nM). Inhibits organic ion transporters and Hsp90. Active in vitro and in vivo .

一般描述

Novobiocin Sodium 是一种非常有效的细菌DNA旋转酶和人体有机阴离子转运体，作用于hOAT1，hOAT3和hOAT4，Ki分别为14.87±0.40μM, 4.77±1.12μM 和 90.50±7.50μM。An Hsp90 and DNA gyrase inhibitor.

Novobiocin Sodium is a very potent bacterial DNA gyrase and human organic anion transporters with Ki of 14.87 ± 0.40 μM for hOAT1, 4.77 ± 1.12 μM for hOAT3 and 90.50 ± 7.50 μM for hOAT4.
An Hsp90 and DNA gyrase inhibitor.

相关属性

CAS编号 1476-53-5
熔点 215°C
溶解性 DMSO 127 mg/mL Water 127 mg/mL Ethanol 127 mg/mL
储存温度 -20°C储存
RTECS RD5425000
分子量 634.61
分子式 C31H35N2NaO11
EC号 216-023-6
品牌 Jinpan
备注 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
PubChem CID 54730021