Oligomycin(Synonyms: 寡霉素)

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Oligomycin (Synonyms: 寡霉素) 纯度: 98.53%

Oligomycin 是一种抗真菌抗生素，是 H+-ATP 合成酶的抑制剂。Oligomycin 断氧化磷酸化和电子传递链。Oligomycin 抑制缺氧性肿瘤细胞 HIF-1alpha 表达。

Oligomycin(Synonyms: 寡霉素)

Oligomycin Chemical Structure

CAS No. : 1404-19-9

规格 价格 是否有货 数量
2 mg ￥880 In-stock
5 mg ￥1400 In-stock
10 mg ￥2200 In-stock
25 mg ￥4600 In-stock
50 mg ￥7800 In-stock
100 mg ￥13200 In-stock
200 mg   询价  
500 mg   询价  

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Oligomycin 相关产品

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生物活性

Oligomycin, an antifungal antibiotic, is an inhibitor of H+-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells[1][2][3][4].

体外研究
(In Vitro)

Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
CAS 号

1404-19-9
中文名称

寡霉素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶解性数据
In Vitro: 

Ethanol : 30 mg/mL (Need ultrasonic and warming)

DMSO : 20 mg/mL (Need ultrasonic and warming)
参考文献

  • [1]. Zhou W, et al. Membrane plasticity facilitates recognition of the inhibitor oligomycin by the mitochondrial ATP synthase rotor. Biochim Biophys Acta Bioenerg. 2018;1859(9):789-796.

    [2]. SMITH RM, et al. Oligomycin, a new antifungal antibiotic. Antibiot Chemother (Northfield). 1954;4(9):962-970.

    [3]. López de Figueroa P, et al. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67(4):966-976.

    [4]. Gong Y, et al. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells. Am J Physiol Cell Physiol. 2005;288(5):C1023-C1029.

    [5]. Shchepina LA, et al. Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis. Oncogene. 2002;21(53):8149-8157.

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