Menin-MLL inhibitor 20

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Menin-MLL inhibitor 20 

Menin-MLL inhibitor 20 是一种不可逆的 menin-MLL 相互作用的抑制剂，具有抗肿瘤活性 (WO2020142557A1, compound 6)。

Menin-MLL inhibitor 20

Menin-MLL inhibitor 20 Chemical Structure

CAS No. : 2448173-47-3

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100 mg ￥14500 In-stock
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Menin-MLL inhibitor 20 相关产品

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生物活性

Menin-MLL inhibitor 20 is an irreversible menin-MLL interaction inhibitor with antitumor activities (WO2020142557A1, compound 6)[1].

体外研究
(In Vitro)

The Histone-lysine N-methyltransferase 2 (KMT2) family of proteins, which currently consists of at least 5 members, methylate ly sine 4 on the histone H3 tails at important regulatory regions in the genome and thereby impart crucial functions through the modulation of chromatin structures and DNA accessibility. These enzymes are known to play an important role in the regulation of gene expression during early development and hematopoiesis. The human KMT2 family was initially named the mixed-lineage leukaemia (MLL) family, owing to the role of the first-found member in this disease[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

612.72

Formula

C33H40N8O4
CAS 号

2448173-47-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 33.33 mg/mL (54.40 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6321 mL 8.1603 mL 16.3207 mL
5 mM 0.3264 mL 1.6321 mL 3.2641 mL
10 mM 0.1632 mL 0.8160 mL 1.6321 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Thomas Butler, et al. Irreversible inhibitors of menin-mll interaction. WO2020142557A1.

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