上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
Isatuximab
Isatuximab 是一种单克隆抗体，靶向跨膜受体和胞外酶 CD38，一种在血液系统恶性细胞，包括多发性骨髓瘤中高度表达的蛋白。Isatuximab 通过多种生物学机制具有抗肿瘤活性，包括抗体依赖性细胞介导的细胞毒性、补体依赖性细胞毒性、抗体依赖性细胞吞噬作用和无交联直接诱导细胞凋亡 (apoptosis)。Isatuximab 还直接抑制 CD38 胞外酶活性，这与许多细胞功能有关。
Isatuximab Chemical Structure
CAS No. : 1461640-62-9
| 规格 | 价格 | 是否有货 | |
|---|---|---|---|
| 1 mg | ￥3500 | 询问价格 & 货期 | |
| 5 mg | ￥8600 | 询问价格 & 货期 | |
| 10 mg | ￥14500 | 询问价格 & 货期 | |
* Please select Quantity before adding items.
| 生物活性 |
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions[1][2]. |
|---|---|
| 体外研究 (In Vitro) |
An in-vitro study shows that the combination of Isatuximab with Pomalidomide (an immunomodulatory drug) results in greater direct toxicity and lysis of CD38 multiple myeloma cells by effector cells compared with Isatuximab alone[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
| Clinical Trial |
|
| CAS 号 |
1461640-62-9 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
|
所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务