Desmethyl-QCA276(Synonyms: PROTAC BRD4-binding moiety 4)

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Desmethyl-QCA276 (Synonyms: PROTAC BRD4-binding moiety 4)

Desmethyl-QCA276 (PROTAC BRD4-binding moiety 4)，以 QCA276 为基础结构，通过一个 linker 与 cereblon 配体结合形成 PROTAC 来降解 BET。QCA276 是一种 BET 抑制剂，其 IC50 值为 10 nM，Ki 值为 2.3 nM。

Desmethyl-QCA276(Synonyms: PROTAC BRD4-binding moiety 4)

Desmethyl-QCA276 Chemical Structure

CAS No. : 2126819-55-2

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生物活性

Desmethyl-QCA276 (PROTAC BRD4-binding moiety 4), the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1].

分子量

387.46

Formula

C21H17N5OS
CAS 号

2126819-55-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Qin C, et al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.

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