VES-POFP

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

VES-POFP 

VES-POFP 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

VES-POFP

VES-POFP Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

VES-POFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

696.83

Formula

C39H53F5O5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

VES-POFP

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

VES-POFP 

VES-POFP 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

VES-POFP

VES-POFP Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

VES-POFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

696.83

Formula

C39H53F5O5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

VES-POFP

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

VES-POFP 

VES-POFP 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

VES-POFP

VES-POFP Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

VES-POFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

696.83

Formula

C39H53F5O5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC BRD4 Degrader-15

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC BRD4 Degrader-15 

PROTAC BRD4 Degrader-15 是一种由von Hippel-Lindau配体和BRD4配体相连的PROTAC,对 BRD4 BD1BD2IC50 值分别为 7.2 nM 和 8.1 nM。PROTAC BRD4 Degrader-15 能够有效降解 PC3 前列腺癌细胞中的 BRD4 蛋白。

PROTAC BRD4 Degrader-15

PROTAC BRD4 Degrader-15 Chemical Structure

CAS No. : 2417370-67-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC BRD4 Degrader-15 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4, with IC50s of 7.2 nM and 8.1 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-15 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1].

IC50 & Target[1]

BRD4 BD1

7.2 nM (IC50)

BRD4 BD2

8.1 nM (IC50)

体外研究
(In Vitro)

PROTAC BRD4 Degrader-15 (compound 13) (4 h) inhibits suppresses MYC gene transcript in MV4-11 AML cells, with an IC50 of 15 nM[1].
PROTAC BRD4 Degrader-15 (6 days) inhibits the proliferation of HL-60 and PC3-S1 cells, with an IC50 of 4.2 nM and 91 nM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1149.29

Formula

C57H62F2N10O10S2

CAS 号

2417370-67-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC BRD4 Degrader-15

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC BRD4 Degrader-15 

PROTAC BRD4 Degrader-15 是一种由von Hippel-Lindau配体和BRD4配体相连的PROTAC,对 BRD4 BD1BD2IC50 值分别为 7.2 nM 和 8.1 nM。PROTAC BRD4 Degrader-15 能够有效降解 PC3 前列腺癌细胞中的 BRD4 蛋白。

PROTAC BRD4 Degrader-15

PROTAC BRD4 Degrader-15 Chemical Structure

CAS No. : 2417370-67-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC BRD4 Degrader-15 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4, with IC50s of 7.2 nM and 8.1 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-15 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1].

IC50 & Target[1]

BRD4 BD1

7.2 nM (IC50)

BRD4 BD2

8.1 nM (IC50)

体外研究
(In Vitro)

PROTAC BRD4 Degrader-15 (compound 13) (4 h) inhibits suppresses MYC gene transcript in MV4-11 AML cells, with an IC50 of 15 nM[1].
PROTAC BRD4 Degrader-15 (6 days) inhibits the proliferation of HL-60 and PC3-S1 cells, with an IC50 of 4.2 nM and 91 nM[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1149.29

Formula

C57H62F2N10O10S2

CAS 号

2417370-67-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC BRD4 Degrader-15

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC BRD4 Degrader-15 

PROTAC BRD4 Degrader-15 是一种由von Hippel-Lindau配体和BRD4配体相连的PROTAC,对 BRD4 BD1BD2IC50 值分别为 7.2 nM 和 8.1 nM。PROTAC BRD4 Degrader-15 能够有效降解 PC3 前列腺癌细胞中的 BRD4 蛋白。

PROTAC BRD4 Degrader-15

PROTAC BRD4 Degrader-15 Chemical Structure

CAS No. : 2417370-67-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC BRD4 Degrader-15 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4, with IC50s of 7.2 nM and 8.1 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-15 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1].

IC50 & Target[1]

BRD4 BD1

7.2 nM (IC50)

BRD4 BD2

8.1 nM (IC50)

体外研究
(In Vitro)

PROTAC BRD4 Degrader-15 (compound 13) (4 h) inhibits suppresses MYC gene transcript in MV4-11 AML cells, with an IC50 of 15 nM[1].
PROTAC BRD4 Degrader-15 (6 days) inhibits the proliferation of HL-60 and PC3-S1 cells, with an IC50 of 4.2 nM and 91 nM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1149.29

Formula

C57H62F2N10O10S2

CAS 号

2417370-67-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC IRAK4 degrader-4

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC IRAK4 degrader-4 

PROTAC IRAK4 degrader-4 是一种基于 CereblonIRAK4 降解剂 PROTAC,详细信息请参考专利文献 US20190192668A1 中的化合物 I-127。

PROTAC IRAK4 degrader-4

PROTAC IRAK4 degrader-4 Chemical Structure

CAS No. : 2360528-45-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC IRAK4 degrader-4 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-127[1].

IC50 & Target[1]

IRAK4

 

体外研究
(In Vitro)

PROTAC IRAK4 degrader-4 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

901.80

Formula

C41H38F3N11O10

CAS 号

2360528-45-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. US20190192668A1

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC IRAK4 degrader-5

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC IRAK4 degrader-5 

PROTAC IRAK4 Degrader-5 是一种基于 CereblonIRAK4 降解剂,详细信息请参考专利文献 US20190192668A1 中的化合物 I-171。

PROTAC IRAK4 degrader-5

PROTAC IRAK4 degrader-5 Chemical Structure

CAS No. : 2360530-61-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader extracted from patent US20190192668A1, compound I-171[1].

IC50 & Target[1]

IRAK4

 

分子量

887.82

Formula

C41H40F3N11O9

CAS 号

2360530-61-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Mainolfi N, et, al. Irak degraders and uses thereof. US20190192668A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC IRAK4 degrader-6

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC IRAK4 degrader-6 

PROTAC IRAK4 degrader-6 是一种基于 CereblonIRAK4 降解剂 PROTAC,详细信息请参考专利文献 US20190192668A1 中的化合物 I-127。

PROTAC IRAK4 degrader-6

PROTAC IRAK4 degrader-6 Chemical Structure

CAS No. : 2360530-72-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC IRAK4 degrader-6 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-172[1].

IC50 & Target[1]

IRAK4

 

体外研究
(In Vitro)

PROTAC IRAK4 degrader-6 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

898.85

Formula

C42H41F3N12O8

CAS 号

2360530-72-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. https://scifinder-n.cas.org/patent-viewer?docuri=g__2-GF3YbbKfwweYAYLNnmYDIpK1sFeQGP9cmlPB_4&markedFullTextKey=GFB6kc_cFl60fBy8t-u8qupJE998gaydSFApjgE-p5c.pdf

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC IRAK4 degrader-4

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC IRAK4 degrader-4 

PROTAC IRAK4 degrader-4 是一种基于 CereblonIRAK4 降解剂 PROTAC,详细信息请参考专利文献 US20190192668A1 中的化合物 I-127。

PROTAC IRAK4 degrader-4

PROTAC IRAK4 degrader-4 Chemical Structure

CAS No. : 2360528-45-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC IRAK4 degrader-4 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-127[1].

IC50 & Target[1]

IRAK4

 

体外研究
(In Vitro)

PROTAC IRAK4 degrader-4 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

901.80

Formula

C41H38F3N11O10

CAS 号

2360528-45-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. US20190192668A1

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC IRAK4 degrader-5

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC IRAK4 degrader-5 

PROTAC IRAK4 Degrader-5 是一种基于 CereblonIRAK4 降解剂,详细信息请参考专利文献 US20190192668A1 中的化合物 I-171。

PROTAC IRAK4 degrader-5

PROTAC IRAK4 degrader-5 Chemical Structure

CAS No. : 2360530-61-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader extracted from patent US20190192668A1, compound I-171[1].

IC50 & Target[1]

IRAK4

 

分子量

887.82

Formula

C41H40F3N11O9

CAS 号

2360530-61-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Mainolfi N, et, al. Irak degraders and uses thereof. US20190192668A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC IRAK4 degrader-4

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC IRAK4 degrader-4 

PROTAC IRAK4 degrader-4 是一种基于 CereblonIRAK4 降解剂 PROTAC,详细信息请参考专利文献 US20190192668A1 中的化合物 I-127。

PROTAC IRAK4 degrader-4

PROTAC IRAK4 degrader-4 Chemical Structure

CAS No. : 2360528-45-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC IRAK4 degrader-4 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-127[1].

IC50 & Target[1]

IRAK4

 

体外研究
(In Vitro)

PROTAC IRAK4 degrader-4 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

901.80

Formula

C41H38F3N11O10

CAS 号

2360528-45-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. US20190192668A1

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC IRAK4 degrader-6

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC IRAK4 degrader-6 

PROTAC IRAK4 degrader-6 是一种基于 CereblonIRAK4 降解剂 PROTAC,详细信息请参考专利文献 US20190192668A1 中的化合物 I-127。

PROTAC IRAK4 degrader-6

PROTAC IRAK4 degrader-6 Chemical Structure

CAS No. : 2360530-72-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC IRAK4 degrader-6 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-172[1].

IC50 & Target[1]

IRAK4

 

体外研究
(In Vitro)

PROTAC IRAK4 degrader-6 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

898.85

Formula

C42H41F3N12O8

CAS 号

2360530-72-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. https://scifinder-n.cas.org/patent-viewer?docuri=g__2-GF3YbbKfwweYAYLNnmYDIpK1sFeQGP9cmlPB_4&markedFullTextKey=GFB6kc_cFl60fBy8t-u8qupJE998gaydSFApjgE-p5c.pdf

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PROTAC IRAK4 degrader-5

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC IRAK4 degrader-5 

PROTAC IRAK4 Degrader-5 是一种基于 CereblonIRAK4 降解剂,详细信息请参考专利文献 US20190192668A1 中的化合物 I-171。

PROTAC IRAK4 degrader-5

PROTAC IRAK4 degrader-5 Chemical Structure

CAS No. : 2360530-61-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader extracted from patent US20190192668A1, compound I-171[1].

IC50 & Target[1]

IRAK4

 

分子量

887.82

Formula

C41H40F3N11O9

CAS 号

2360530-61-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Mainolfi N, et, al. Irak degraders and uses thereof. US20190192668A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC IRAK4 degrader-6

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC IRAK4 degrader-6 

PROTAC IRAK4 degrader-6 是一种基于 CereblonIRAK4 降解剂 PROTAC,详细信息请参考专利文献 US20190192668A1 中的化合物 I-127。

PROTAC IRAK4 degrader-6

PROTAC IRAK4 degrader-6 Chemical Structure

CAS No. : 2360530-72-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC IRAK4 degrader-6 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-172[1].

IC50 & Target[1]

IRAK4

 

体外研究
(In Vitro)

PROTAC IRAK4 degrader-6 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

898.85

Formula

C42H41F3N12O8

CAS 号

2360530-72-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. https://scifinder-n.cas.org/patent-viewer?docuri=g__2-GF3YbbKfwweYAYLNnmYDIpK1sFeQGP9cmlPB_4&markedFullTextKey=GFB6kc_cFl60fBy8t-u8qupJE998gaydSFApjgE-p5c.pdf

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC PTK6 ligand-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC PTK6 ligand-1 

PROTAC PTK6 ligand-1 是 BTK 激酶抑制剂合成的中间体。PROTAC PTK6 ligand-1 可用于 ARD-61 (HY-139659) 的合成。

PROTAC PTK6 ligand-1

PROTAC PTK6 ligand-1 Chemical Structure

CAS No. : 2408341-98-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC PTK6 ligand-1 is an intermediate for BTK kinase inhibitor preparation[1]. PROTAC PTK6 ligand-1 can be used in the synthesis of ARD-61 (HY-139659)[2].

分子量

540.63

Formula

C27H32N4O6S

CAS 号

2408341-98-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pyrrolo-aromatic heterocyclic compound, preparation method therefor, and medical use thereof. Patent WO2020010204.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC PTK6 ligand-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC PTK6 ligand-1 

PROTAC PTK6 ligand-1 是 BTK 激酶抑制剂合成的中间体。PROTAC PTK6 ligand-1 可用于 ARD-61 (HY-139659) 的合成。

PROTAC PTK6 ligand-1

PROTAC PTK6 ligand-1 Chemical Structure

CAS No. : 2408341-98-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC PTK6 ligand-1 is an intermediate for BTK kinase inhibitor preparation[1]. PROTAC PTK6 ligand-1 can be used in the synthesis of ARD-61 (HY-139659)[2].

分子量

540.63

Formula

C27H32N4O6S

CAS 号

2408341-98-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pyrrolo-aromatic heterocyclic compound, preparation method therefor, and medical use thereof. Patent WO2020010204.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC PTK6 ligand-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC PTK6 ligand-1 

PROTAC PTK6 ligand-1 是 BTK 激酶抑制剂合成的中间体。PROTAC PTK6 ligand-1 可用于 ARD-61 (HY-139659) 的合成。

PROTAC PTK6 ligand-1

PROTAC PTK6 ligand-1 Chemical Structure

CAS No. : 2408341-98-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC PTK6 ligand-1 is an intermediate for BTK kinase inhibitor preparation[1]. PROTAC PTK6 ligand-1 can be used in the synthesis of ARD-61 (HY-139659)[2].

分子量

540.63

Formula

C27H32N4O6S

CAS 号

2408341-98-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pyrrolo-aromatic heterocyclic compound, preparation method therefor, and medical use thereof. Patent WO2020010204.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC BRD4 ligand-2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC BRD4 ligand-2 

PROTAC BRD4 ligand-2 是一种靶蛋白 BRD4 的配体,用于 PROTAC CFT-2718 的合成。

PROTAC BRD4 ligand-2

PROTAC BRD4 ligand-2 Chemical Structure

CAS No. : 2154358-11-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718.

分子量

400.86

Formula

C22H17ClN6

CAS 号

2154358-11-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sun D, et al. Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models. Mol Cancer Ther. 2021 Aug;20(8):1367-1377.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC BRD4 ligand-2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC BRD4 ligand-2 

PROTAC BRD4 ligand-2 是一种靶蛋白 BRD4 的配体,用于 PROTAC CFT-2718 的合成。

PROTAC BRD4 ligand-2

PROTAC BRD4 ligand-2 Chemical Structure

CAS No. : 2154358-11-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718.

分子量

400.86

Formula

C22H17ClN6

CAS 号

2154358-11-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sun D, et al. Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models. Mol Cancer Ther. 2021 Aug;20(8):1367-1377.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务