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Belvarafenib TFA (Synonyms: HM95573 TFA; GDC-5573 TFA; RG6185 TFA) 纯度: ≥99.0%
Belvarafenib TFA (HM95573 TFA) 是一种有效的，广泛的迅速加速纤维肉瘤激酶 (RAF) 的抑制剂，其对 B-RAF，B-RAFv600E 和C-RAF 的 IC50 值分别为 56 nM, 7 nM 和 5 nM。
Belvarafenib TFA Chemical Structure
| 规格 | 价格 | 是否有货 | |
|---|---|---|---|
| 5 mg | ￥1800 | 询问价格 & 货期 | |
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Belvarafenib TFA 的其他形式现货产品:
| 生物活性 |
Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively[1]. |
IC50 & Target |
IC50: 56 nM(B-RAF), 7 nM(B-RAFv600E), 5 nM(C-RAF)[1]. |
|---|---|
| 体外研究 (In Vitro) |
Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
| Clinical Trial |
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| 分子量 |
592.95 |
| Formula |
C25H17ClF4N6O3S |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| 参考文献 |
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