(Rac)-Idroxioleic acid(Synonyms: 2-Hydroxyoleic acid; 2-OHOA)

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(Rac)-Idroxioleic acid (Synonyms: 2-Hydroxyoleic acid; 2-OHOA) 纯度: ≥98.0%

(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) 是一种合成油酸 (OA) 衍生物，能与质膜结合改变脂质组织。(Rac)-Idroxioleic acid 具有抗肿瘤作用。

(Rac)-Idroxioleic acid(Synonyms: 2-Hydroxyoleic acid; 2-OHOA)

(Rac)-Idroxioleic acid Chemical Structure

CAS No. : 56472-29-8

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生物活性

(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect[1].

体外研究
(In Vitro)

(Rac)-Idroxioleic acid (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM[1].
(Rac)-Idroxioleic acid (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Jurkat cells
Concentration: 25 μM, 50 μM, 75 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Impaired Jurkat cell growth in a time- and concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: Jurkat cells
Concentration: 25 μM, 50 μM
Incubation Time: 72 hours
Result: Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP.

体内研究
(In Vivo)

(Rac)-Idroxioleic acid markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old nude male mice (Jurkat cells xenograft model)[1]
Dosage: 600 mg/kg
Administration: Oral administration; daily; for 21 days
Result: Markedly and significantly inhibited tumour growth.

Clinical Trial

分子量

298.46

Formula

C18H34O3
CAS 号

56472-29-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Llado V, et al. Minerval induces apoptosis in Jurkat and other cancer cells. J Cell Mol Med. 2010 Mar;14(3):659-70.

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