TP-472

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

TP-472 

TP-472 是一种选择性的 BRD7/9 抑制剂，对 BRD7 和 BRD9 作用的 KD 值分别为 0.34 μM 和 33 nM。

TP-472

TP-472 Chemical Structure

CAS No. : 2079895-62-6

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生物活性

TP-472 is a selective BRD7/9 inhibitor, with KDs of 0.34 μM and 33 nM for BRD7 and BRD9, respectively[1][2].

IC50 & Target[1]

BRD7

0.34 μM (Kd)

BRD9

33 nM (Kd)

体外研究
(In Vitro)

TP-472 has a high potency for BRD9 (Kd= 33 nM) and BRD7 (Kd= 0.34 μM), with >30-fold selectivity over other Brds[1].
TP-472 (1 µM, 3 µM; 24-216 hours) yields concentration-dependent growth defects in ESCs[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: ESCs
Concentration: 1 µM, 3 µM
Incubation Time: 24 hours, 72 hours, 120 hours, 168 hours, 216 hours
Result: Yields concentration-dependent growth defects in ESCs.

分子量

333.38

Formula

C20H19N3O2
CAS 号

2079895-62-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Moustakim M, et al. Chemical probes and inhibitors of bromodomains outside the BET family. Medchemcomm. 2016 Dec 7;7(12):2246-2264.

    [2]. Gatchalian J, et al. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Nat Commun. 2018 Dec 3;9(1):5139.

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