Z-Ile-Leu-aldehyde(Synonyms: Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Z-Ile-Leu-aldehyde (Synonyms: Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII) 纯度: ≥98.0%

Z-Ile-Leu-aldehyde (Z-IL-CHO) 是有效的、竞争性的 γ-secretasenotch 的肽醛抑制剂。

Z-Ile-Leu-aldehyde(Synonyms: Z-IL-CHO;  GSI-XII;  γ-Secretase inhibitor XII)

Z-Ile-Leu-aldehyde Chemical Structure

CAS No. : 161710-10-7

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥2791 In-stock
2 mg ¥2333 In-stock
5 mg ¥3500 In-stock
10 mg ¥5000 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Z-Ile-Leu-aldehyde 相关产品

相关化合物库:

  • Covalent Screening Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Neuronal Signaling Compound Library
  • Stem Cell Signaling Compound Library
  • Wnt/Hedgehog/Notch Compound Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Covalent Screening Library
  • Differentiation Inducing Compound Library
  • Reprogramming Compound Library
  • Anti-Breast Cancer Compound Library
  • Anti-Pancreatic Cancer Compound Library
  • Anti-Blood Cancer Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Angiogenesis Related Compound Library
  • Transcription Factor Targeted Library
  • Anti-Liver Cancer Compound Library
  • Anti-Colorectal Cancer Compound Library

生物活性

Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch[1][2].

体外研究
(In Vitro)

Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays[1].
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCRsup>[1]

Cell Line: CD4+ T cells from C57BL/6 mice.
Concentration: 25 μM.
Incubation Time: 24, 48, 72 hours.
Result: DownregulateD RORt and IL-17 mRNA expression.

Cell Viability Assaysup>[2]

Cell Line: MOPC315.BM cells.
Concentration: 0, 12, 15 μM.
Incubation Time: 24-48 h hours.
Result: Reduced viability and induced apoptosis in MOPC315.BM cells

体内研究
(In Vivo)

Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MOPC315.BM mouse model[2].
Dosage: 10 mg/kg.
Administration: Intraperitoneally either for 14 days.
Result: Reduces myeloma-specific paraprotein levels in the MOPC315.BM model.
Diminished osteolytic lesions in the MOPC315.BM mice.

分子量

362.46

Formula

C20H30N2O4

CAS 号

161710-10-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 41 mg/mL (113.12 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7589 mL 13.7946 mL 27.5893 mL
5 mM 0.5518 mL 2.7589 mL 5.5179 mL
10 mM 0.2759 mL 1.3795 mL 2.7589 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Reem Suleiman, et al. The Role Of Notch In Th17 Differentiation. University of Massachusetts Amherst. 9-2013.

    [2]. Schwarzer R, et al. Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model. Blood Cancer J. 2014 Jun 13;4:e217.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务