CB30865(Synonyms: ZM 242421)

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CB30865 (Synonyms: ZM 242421) 纯度: 98.05%

CB30865 (ZM 242421) 是一种烟酰胺磷酸核糖转移酶 (Nampt) 抑制剂，具有很强的细胞毒性。CB30865 在体外能抑制多种人类肿瘤细胞系 (IC50 值在 1-10 nM 范围内)。

CB30865(Synonyms: ZM 242421)

CB30865 Chemical Structure

CAS No. : 206275-15-2

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3022 In-stock
5 mg ￥2660 In-stock
10 mg ￥3432 In-stock
50 mg ￥9263 In-stock
100 mg ￥13020 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

CB30865 相关产品

•相关化合物库:

  • Covalent Screening Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Anti-Cancer Compound Library
  • Covalent Screening Library

生物活性

CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC50 values in the 1-10 nM range)[1][2].

体外研究
(In Vitro)

CB30865 exhibits cytotoxicity due to NAD reduction via Nampt inhibition[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

516.39

Formula

C26H22BrN5O2
CAS 号

206275-15-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 33.33 mg/mL (64.54 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9365 mL 9.6826 mL 19.3652 mL
5 mM 0.3873 mL 1.9365 mL 3.8730 mL
10 mM 0.1937 mL 0.9683 mL 1.9365 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Fleischer TC, et al. Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound. Chem Biol. 2010 Jun 25;17(6):659-664.

    [2]. Skelton LA, et al. Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action. Cytometry. 1998 Sep 1;33(1):56-66.

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