Camptothecin-20(S)-O-propionate(Synonyms: Camptothecin-20-O-propionate)

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Camptothecin-20(S)-O-propionate (Synonyms: Camptothecin-20-O-propionate) 纯度: 98.43%

Camptothecin-20(S)-O-propionate (CZ48) 是喜树碱 (CPT) 的类似物，是强效的抗肿瘤化合物。Camptothecin-20(S)-O-propionate (CZ48) 是拓扑异构酶 I (topoisomerase-Ι) 的抑制剂。

Camptothecin-20(S)-O-propionate(Synonyms: Camptothecin-20-O-propionate)

Camptothecin-20(S)-O-propionate Chemical Structure

CAS No. : 194414-69-2

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3850 In-stock
5 mg ￥3500 In-stock
10 mg ￥5800 In-stock
50 mg ￥16500 In-stock
100 mg ￥25500 In-stock
200 mg   询价  
500 mg   询价  

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Camptothecin-20(S)-O-propionate 相关产品

•相关化合物库:

  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Cell Cycle/DNA Damage Compound Library
  • Anti-Cancer Compound Library
  • Clinical Compound Library
  • Anti-Aging Compound Library
  • Anti-Lung Cancer Compound Library

生物活性

Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3].

体内研究
(In Vivo)

Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A tumor xenograft growing in a nude mouse (size, ∼1 cm3)[3].
Dosage: 100-1000 mg/kg/day.
Administration: Oral gavage, for 2, 4 and 6 days, respectively.
Result: Exhibited anti-tumor effect.

Clinical Trial

分子量

404.42

Formula

C23H20N2O5
CAS 号

194414-69-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 9.09 mg/mL (22.48 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4727 mL 12.3634 mL 24.7268 mL
5 mM 0.4945 mL 2.4727 mL 4.9454 mL
10 mM 0.2473 mL 1.2363 mL 2.4727 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9.

    [2]. Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9.

    [3]. Xing Liu, et al. Correlation between the sensitivity of tumors to treatment with CZ48 and local concentrations of the active metabolite CPT within the tumors. Biomed Rep. 2013 Mar;1(2):202-206.

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