Tos-PEG4-THP

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Tos-PEG4-THP 

Tos-PEG4-THP 是一种 PROTAC linker,属于 PEG 类。Tetraethylene glycol 可用于合成 PROTAC K-Ras Degrader-1 (HY-129523)。

Tos-PEG4-THP

Tos-PEG4-THP Chemical Structure

CAS No. : 86259-89-4

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500 mg ¥3500 In-stock
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5 g   询价  

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生物活性

Tos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1].

IC50 & Target[1]

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

432.53

Formula

C20H32O8S

CAS 号

86259-89-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

参考文献
  • [1]. Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2.

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