上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
SSE15206 纯度: 98.39%
SSE15206 是一种微管 (microtubule) 聚合抑制剂,其在 HCT116 细胞中的 GI50 值为 197 nM,能克服多重耐药性。引起细胞中纺锤体形成不完全,从而导致 G2/M 阻滞,有丝分裂异常。
SSE15206 Chemical Structure
CAS No. : 1370046-40-4
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥759 | In-stock | |
5 mg | ¥690 | In-stock | |
10 mg | ¥870 | In-stock | |
25 mg | ¥1800 | In-stock | |
50 mg | ¥2800 | In-stock | |
100 mg | ¥4100 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
SSE15206 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- Cell Cycle/DNA Damage Compound Library
- Anti-Cancer Compound Library
- Anti-Aging Compound Library
- Cytoskeleton Compound Library
- Anti-Lung Cancer Compound Library
- Targeted Diversity Library
生物活性 |
SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells[1]. |
IC50 & Target |
GI50: 197 nM (microtubule)[1]. |
||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
体外研究 (In Vitro) |
SSE15206 induces apoptosis in cells irrespective of MDR-1 overexpression cell lines (KB-V1, A2780-Pac-Res), highly resistant to paclitaxel cells (HCT116-Pac-Res) and parental cells at the concentration of 5 × and 10 × GI50 values. To conclude, SSE15206 is able to overcome resistance to chemotherapeutic drugs such as paclitaxel in different cancer cell lines[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[1]
|
||||||||||||||||
分子量 |
371.45 |
||||||||||||||||
Formula |
C19H21N3O3S |
||||||||||||||||
CAS 号 |
1370046-40-4 |
||||||||||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
储存方式 |
|
||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : 150 mg/mL (403.82 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
||||||||||||||||
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务