BEBT-908(Synonyms: PI3Kα inhibitor 1)

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BEBT-908 (Synonyms: PI3Kα inhibitor 1) 纯度: 99.14%

BEBT-908 (PI3Kα inhibitor 1) 是一种选择性的 PI3Kα 抑制剂，IC50<0.1 μM, 也抑制 HDAC (0.1 μM≤IC50≤1 μM) ，详细信息请参考专利文献 US/20120088764A1 中的化合物 243。

BEBT-908(Synonyms: PI3Kα inhibitor 1)

BEBT-908 Chemical Structure

CAS No. : 1235449-52-1

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3520 In-stock
5 mg ￥3200 In-stock
10 mg ￥4800 In-stock
50 mg ￥13800 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

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生物活性

BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor extracted from patent US/20120088764A1, Compound 243, has an IC50<0.1 μM, PI3Kα inhibitor 1 also inhibits HDAC (0.1 μM≤IC50≤1 μM) .

IC50 & Target[1]

PI3Kα

0.1 μM (IC50)

HDAC

0.1 μM (IC50)

分子量

507.57

Formula

C23H25N9O3S
CAS 号

1235449-52-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 37 mg/mL (72.90 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9702 mL 9.8509 mL 19.7017 mL
5 mM 0.3940 mL 1.9702 mL 3.9403 mL
10 mM 0.1970 mL 0.9851 mL 1.9702 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Cai Xiong, et al. Deazapurines, thienopyrimidines and furopyrimidines as phosphoinositide 3-kinase inhibitors with a zinc binding moiety and their preparation and use in the treatment of diseases. From U.S. Pat. Appl. Publ. (2012), US 20120088764 A1 20120412.

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