上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
PF-06843195 纯度: 99.06%
PF-06843195 是一种高度选择性的 PI3Kα 抑制剂,在 Rat1 成纤维细胞中,其 IC50 为 18 nM。PF-06843195 作用于 PI3Kα 和 PI3Kδ 的 Ki 分别小于 0.018 nM 和 0.28 nM。PF-06843195对 PI3K/mTOR 信号通路有明显抑制作用,且具有持久的抗肿瘤作用。
PF-06843195 Chemical Structure
CAS No. : 2067281-51-8
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥5000 | In-stock | |
10 mg | ¥8500 | In-stock | |
25 mg | ¥18000 | In-stock | |
50 mg | ¥31000 | In-stock | |
100 mg | ¥47000 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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PF-06843195 相关产品
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生物活性 |
PF-06843195 is a highly selective PI3Kα inhibitor with an IC50 of 18 nM in Rat1 fibroblasts. The Kis of PF-06843195 for PI3Kα and PI3Kδ in biochemical kinase assay are less than 0.018 nM and 0.28 nM, respectively. PF-06843195 has great suppression of the PI3K/mTOR signaling pathway and durable antitumor efficacy[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
PF-06843195 inhibits the breast cancer cell lines MCF7 and T47D proliferation with IC50s of 62 nM and 32 nM, respectively[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
In rats, PF-06843195 can rapidly and quantitatively transform from PF-06862309[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
498.46 |
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Formula |
C20H25F3N8O4 |
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CAS 号 |
2067281-51-8 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 62.5 mg/mL (125.39 mM; ultrasonic and warming and heat to 60°C) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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