1-Caffeoylquinic acid

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1-Caffeoylquinic acid  纯度: ≥98.0%

1-Caffeoylquinic acid 1-咖啡酰奎宁酸是一种有效的 NF-κB 抑制剂，对 p105 的 RH 结构域显示高结合亲和力，Ki 值为 0.002 μM，结合能为 1.50 Kcal/mol。1-Caffeoylquinic acid 具有抗氧化应激能力。 1-Caffeoylquinic acid 抑制 PD-1/PD-L1 相互作用。

1-Caffeoylquinic acid

1-Caffeoylquinic acid Chemical Structure

CAS No. : 1241-87-8

规格 价格 是否有货 数量
1 mg ￥1710 In-stock
5 mg ￥5140 In-stock
10 mg   询价  
50 mg   询价  

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生物活性

1-Caffeoylquinic acid is an effective NF-κB inhibitor, shows significant binding affinity to the RH domain of p105 with Ki of 0.002 μM and binding energy of 1.50 Kcal/mol[1]. 1-Caffeoylquinic acid has anti-oxidative stress ability[2]. 1-Caffeoylquinic acid inhibits PD-1/PD-L1 interact[3].

IC50 & Target

Ki: 0.002 μM (1-Caffeoylquinic acid)[1]
分子量

354.31

Formula

C16H18O9
CAS 号

1241-87-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (705.60 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8224 mL 14.1119 mL 28.2239 mL
5 mM 0.5645 mL 2.8224 mL 5.6448 mL
10 mM 0.2822 mL 1.4112 mL 2.8224 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Khan MK, et al. Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105. Pharmacogn Mag. 2013 Jan;9(33):51-7.

    [2]. Jiang Y, et al. Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model. BMC Complement Altern Med. 2017 Jun 17;17(1):320.

    [3]. Han Y, et al. PD-1/PD-L1 inhibitor screening of caffeoylquinic acid compounds using surface plasmon resonance spectroscopy. Anal Biochem. 2018 Apr 15;547:52-56.

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