(S,R,S)-AHPC-C6-NH2(Synonyms: VH032-C6-NH2)

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(S,R,S)-AHPC-C6-NH2 (Synonyms: VH032-C6-NH2) 纯度: 96.64%

(S,R,S)-AHPC-C6-NH2 (VH032-C6-NH2) 是一种合成的 E3 连接酶配体-linker 偶联物 (E3 ligase ligand-linker conjugate,包含基于 VH032 的 VHL 配体和 1 个 linker,可用于合成 PROTAC 分子。

(S,R,S)-AHPC-C6-NH2(Synonyms: VH032-C6-NH2)

(S,R,S)-AHPC-C6-NH2 Chemical Structure

CAS No. : 2306389-03-5

规格 价格 是否有货 数量
25 mg ¥2000 In-stock
50 mg ¥3500 In-stock
100 mg   询价  
200 mg   询价  

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生物活性

(S,R,S)-AHPC-C6-NH2 (VH032-C6-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology[1].

IC50 & Target

VHL

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

557.75

Formula

C29H43N5O4S

CAS 号

2306389-03-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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