Thalidomide-NH-C6-NH2 TFA

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Thalidomide-NH-C6-NH2 TFA  纯度: 99.82%

Thalidomide-NH-C6-NH2 TFA是一种合成的 E3 连接酶配体 -linker 偶联物,包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。

Thalidomide-NH-C6-NH2 TFA

Thalidomide-NH-C6-NH2 TFA Chemical Structure

CAS No. : 2093386-51-5

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生物活性

Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

486.44

Formula

C21H25F3N4O6

CAS 号

2093386-51-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

参考文献
  • [1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

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Tos-PEG4-NH-Boc(Synonyms: PROTAC Linker 7)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Tos-PEG4-NH-Boc (Synonyms: PROTAC Linker 7)

Tos-PEG4-NH-Boc (PROTAC Linker 7) 是一种 PROTAC linker,属于 PEG 类。Tos-PEG4-NH-Boc 可用于合成 PROTAC 分子。

Tos-PEG4-NH-Boc(Synonyms: PROTAC Linker 7)

Tos-PEG4-NH-Boc Chemical Structure

CAS No. : 1246999-33-6

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生物活性

Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

447.54

Formula

C20H33NO8S

CAS 号

1246999-33-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

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NH2-PEG5-C2-NH-Boc(Synonyms: PROTAC Linker 17)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

NH2-PEG5-C2-NH-Boc (Synonyms: PROTAC Linker 17)

NH2-PEG5-C2-NH-Boc (PROTAC Linker 17) 是一种 PROTAC linker,属于 PEG 类。NH2-PEG5-C2-NH-Boc 可用于合成 PROTAC 分子。

NH2-PEG5-C2-NH-Boc(Synonyms: PROTAC Linker 17)

NH2-PEG5-C2-NH-Boc Chemical Structure

CAS No. : 189209-27-6

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生物活性

NH2-PEG5-C2-NH-Boc (PROTAC Linker 17) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

380.48

Formula

C17H36N2O7

CAS 号

189209-27-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

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HSDVHK-NH2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

HSDVHK-NH2  纯度: 99.63%

HSDVHK-NH2 是整合素 αvβ3-玻璃体结合蛋白的互作抑制剂,其 IC50 值为 1.74 pg/mL (2.414 pM)。

HSDVHK-NH2

HSDVHK-NH2 Chemical Structure

CAS No. : 848644-86-0

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HSDVHK-NH2 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Anti-Cancer Compound Library
  • Cytoskeleton Compound Library
  • Targeted Diversity Library
  • Peptide Library

生物活性

HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM)[1][2].

IC50 & Target

αvβ3

2.74 nM (IC50)

体外研究
(In Vitro)

HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group[1].
The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC50 value of 25.72 nM[2].
HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: HUVEC cells.
Concentration: 0.1, 1, 10, and 100 μg/mL.
Incubation Time: 72 h.
Result: Significantly inhibited HUVEC proliferation on denatured collagen-coated plates in a dose-dependent manner.

分子量

720.78

Formula

C30H48N12O9

CAS 号

848644-86-0

Sequence Shortening

HSDVHK-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

H2O : 250 mg/mL (346.85 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3874 mL 6.9369 mL 13.8739 mL
5 mM 0.2775 mL 1.3874 mL 2.7748 mL
10 mM 0.1387 mL 0.6937 mL 1.3874 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Yoonsuk Lee, et al. High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. J Biomol Screen. 2004 Dec;9(8):687-94.

    [2]. Youngjin Choi, et al. Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Proteomics. 2010 Jan;10(1):72-80.

    [3]. Ji-Young Bang, et al. Pharmacoproteomic analysis of a novel cell-permeable peptide inhibitor of tumor-induced angiogenesis. Mol Cell Proteomics. 2011 Aug;10(8):M110.005264.

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NH2-PEG2-C6-Cl

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

NH2-PEG2-C6-Cl  纯度: ≥95.0%

NH2-PEG2-C6-Cl 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

NH2-PEG2-C6-Cl

NH2-PEG2-C6-Cl Chemical Structure

CAS No. : 744203-60-9

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50 mg ¥1350 In-stock
100 mg ¥1980 In-stock
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生物活性

NH2-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

223.74

Formula

C10H22ClNO2

CAS 号

744203-60-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL (446.95 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.4695 mL 22.3474 mL 44.6947 mL
5 mM 0.8939 mL 4.4695 mL 8.9389 mL
10 mM 0.4469 mL 2.2347 mL 4.4695 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.17 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (11.17 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.17 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (11.17 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.17 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (11.17 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Bis-NH2-C1-PEG3(Synonyms: PROTAC Linker 24)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Bis-NH2-C1-PEG3 (Synonyms: PROTAC Linker 24)

Bis-NH2-C1-PEG3 (PROTAC Linker 24) 是一种 PROTAC linker,属于 PEG 类。Bis-NH2-C1-PEG3 可用于合成 PROTAC 分子。

Bis-NH2-C1-PEG3(Synonyms: PROTAC Linker 24)

Bis-NH2-C1-PEG3 Chemical Structure

CAS No. : 4246-51-9

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生物活性

Bis-NH2-C1-PEG3 (PROTAC Linker 24) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

220.31

Formula

C10H24N2O3

CAS 号

4246-51-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

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Tos-PEG2-NH2(Synonyms: PROTAC Linker 27)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Tos-PEG2-NH2 (Synonyms: PROTAC Linker 27)

Tos-PEG2-NH2 (PROTAC Linker 27) 是一种 PROTAC linker,属于 PEG 类。Tos-PEG2-NH2 可用于合成 PROTAC 分子。

Tos-PEG2-NH2(Synonyms: PROTAC Linker 27)

Tos-PEG2-NH2 Chemical Structure

CAS No. : 1246286-33-8

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50 mg ¥2500 询问价格 & 货期
100 mg ¥4500 询问价格 & 货期
250 mg ¥9500 询问价格 & 货期

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生物活性

Tos-PEG2-NH2 (PROTAC Linker 27) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

259.32

Formula

C11H17NO4S

CAS 号

1246286-33-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

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Boc-NH-PEG-NH2 Cat. No. PG2-AMBC-3k 3400 Da 1 g修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Boc-NH-PEG-NH2

Cat. No. PG2-AMBC-3k
Specification 3400 Da
Unit Size 1 g
Price $385.00

Qty Add to Cart

https://scholar.google.com/scholar?hl=en&as_sdt=0%2C22&q=Nanocs+PEG&btnG=Description:

Boc-NH-PEG-NH2 (Boc PEG amine) is one of Nanocs' heterobifunctional PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. t-Boc protect group in this Boc-PEG-amine compound can be easily deprotected under acidic condition to release free amine for further reaction.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at 4 0C or lower.

References:

Click here to see hundreds of publications from Nanocs PEGs.

Documents
  • SDS
  • DataSheet

BnOH-NH-bis-(C2-S)-propane-O-isoprene ester(Synonyms: PROTAC Linker 29)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

BnOH-NH-bis-(C2-S)-propane-O-isoprene ester (Synonyms: PROTAC Linker 29)

BnOH-NH-bis-(C2-S)-propane-O-isoprene ester (PROTAC Linker 29) 是一种 PROTAC linker,属于 alkyl ether 类。BnOH-NH-bis-(C2-S)-propane-O-isoprene ester 可用于合成 PROTAC 分子。

BnOH-NH-bis-(C2-S)-propane-O-isoprene ester(Synonyms: PROTAC Linker 29)

BnOH-NH-bis-(C2-S)-propane-O-isoprene ester Chemical Structure

CAS No. : 2448704-23-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

BnOH-NH-bis-(C2-S)-propane-O-isoprene ester (PROTAC Linker 29) is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

397.55

Formula

C19H27NO4S2

CAS 号

2448704-23-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Boc-NH-PEG2-C2-amido-C4-acid(Synonyms: PROTAC Linker 30)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Boc-NH-PEG2-C2-amido-C4-acid (Synonyms: PROTAC Linker 30)

Boc-NH-PEG2-C2-amido-C4-acid (PROTAC Linker 30) 是一种 PROTAC linker,属于 PEG 类。Boc-NH-PEG2-C2-amido-C4-acid 可用于合成 PROTAC 分子。

Boc-NH-PEG2-C2-amido-C4-acid(Synonyms: PROTAC Linker 30)

Boc-NH-PEG2-C2-amido-C4-acid Chemical Structure

CAS No. : 1310327-20-8

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生物活性

Boc-NH-PEG2-C2-amido-C4-acid (PROTAC Linker 30) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

376.45

Formula

C17H32N2O7

CAS 号

1310327-20-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21.

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Boc-NH-C6-amido-C4-acid(Synonyms: PROTAC Linker 32)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Boc-NH-C6-amido-C4-acid (Synonyms: PROTAC Linker 32)

Boc-NH-C6-amido-C4-acid (PROTAC Linker 32) 是一种 PROTAC linker,属于 alkyl ether 类。Boc-NH-C6-amido-C4-acid 可用于合成 PROTAC 分子。

Boc-NH-C6-amido-C4-acid(Synonyms: PROTAC Linker 32)

Boc-NH-C6-amido-C4-acid Chemical Structure

CAS No. : 10436-21-2

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生物活性

Boc-NH-C6-amido-C4-acid (PROTAC Linker 32) is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

344.45

Formula

C17H32N2O5

CAS 号

10436-21-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21.

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NH2-Ph-C4-acid-NH2-Me(Synonyms: PROTAC Linker 31)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

NH2-Ph-C4-acid-NH2-Me (Synonyms: PROTAC Linker 31)

NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) 是一种 PROTAC linker,属于 alkyl chain 类。NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) 可用于合成 PROTAC 分子。

NH2-Ph-C4-acid-NH2-Me(Synonyms: PROTAC Linker 31)

NH2-Ph-C4-acid-NH2-Me Chemical Structure

CAS No. : 1263819-48-2

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生物活性

NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl-Chain

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

222.28

Formula

C12H18N2O2

CAS 号

1263819-48-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Leverett CA, et al. Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads. ACS Med Chem Lett. 2016 Aug 26;7(11):999-1004.

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(S,R,S)-AHPC-C8-NH2(Synonyms: VH032-C8-NH2)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

(S,R,S)-AHPC-C8-NH2 (Synonyms: VH032-C8-NH2) 纯度: 95.07%

(S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 VH032 的 VHL 配体和 1 个 linker。(S,R,S)-AHPC-C8-NH2 可用于合成靶向 AKT 的 PROTAC 降解剂,例 8,XF038-164A,源于专利文献 WO2019173516A1。

(S,R,S)-AHPC-C8-NH2(Synonyms: VH032-C8-NH2)

(S,R,S)-AHPC-C8-NH2 Chemical Structure

CAS No. : 2341796-79-8

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生物活性

(S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C8-NH2 is XF038-164A, example 8, extracted from patent WO2019173516A1[1].

IC50 & Target

VHL

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

585.80

Formula

C31H47N5O4S

CAS 号

2341796-79-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Jian Jin, et al. Serine threonine kinase (akt) degradation / disruption compounds and methods of use. Patent WO2019173516A1.

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Boc-NH-PEG-NH2 Cat. No. PG2-AMBC-2k 2000 Da 1 g修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Boc-NH-PEG-NH2

Cat. No. PG2-AMBC-2k
Specification 2000 Da
Unit Size 1 g
Price $385.00

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Description:

Boc-NH-PEG-NH2 is one of Nanocs' heterobifunctional PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. t-Boc protect group in this Boc-PEG-amine compound can be easily deprotected under acidic condition to release free amine for further reaction.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at 4 0C or lower.

References:

Click here to see hundreds publications using Nanocs PEGs.

Documents
  • SDS
  • DataSheet

SF680-NH2, Sun Fluor 680 amine Cat. No. SF680-AM-1 Ex/Em:682/705 2 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SF680-NH2, Sun Fluor 680 amine

Cat. No. SF680-AM-1
Specification Ex/Em:682/705
Unit Size 2 mg
Price $295.00

Qty Add to Cart

Description:

SFTM fluorophores aim to providing better fluorescent molecular tools for our customers. Besides their superior fluorescent properties, e.g. high brightness, super photo-stability, these fluorophores are designed to simplify your fluorescent labeling and detection process. SFTM fluorophores can be used directly in your aqueous working buffer without need adding any organic solvents. Elimination of organic solvents not only simplifies your labeling and detection process, it also provides additional protection of your molecules from damaging caused by some harsh organic solvents. In addition, SFTM fluorophores offer diversified chemically reactive and/or biologically active moieties that can be used directly for labeling, imaging and detecting of various molecules and particles. These fluorophores range from UV to near IR region and can be used both in-vitro and in-vivo imaging. In short, Nanocs SFTM fluorophores offer following advantages:

  • High fluorescent intensity equal or greater than Alexa fluor or cyanine dyes;
  • High photo-stability with proprietary structure;
  • Good water solubility and no organic solvents needed for labeling.
  • Simplified labeling process with high labeling efficiency.

Specifications:

  • Reactive, fast reaction;
  • Soluble in water;

Storage:

Store at -20 0C.


SF680-NH2, Sun Fluor 680 amine           Cat. No. SF680-AM-1    Ex/Em:682/705    2 mg SF680-NH2, Sun Fluor 680 amine           Cat. No. SF680-AM-1    Ex/Em:682/705    2 mg SF680-NH2, Sun Fluor 680 amine           Cat. No. SF680-AM-1    Ex/Em:682/705    2 mg


Boc-NH-PEG-NH2 Cat. No. PG2-AMBC-1k 1000 Da 1 g修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Boc-NH-PEG-NH2

Cat. No. PG2-AMBC-1k
Specification 1000 Da
Unit Size 1 g
Price $385.00

Qty Add to Cart

Description:

Boc-NH-PEG-NH2 (Boc PEG amine) is one of Nanocs' heterobifunctional PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. t-Boc protect group in this Boc-PEG-amine compound can be easily deprotected under acidic condition to release free amine for further reaction.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at 4 0C or lower.

References:

Click here to see hundreds of publications from Nanocs PEGs.

Documents
  • SDS
  • DataSheet

NH2-PEG5-OH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

NH2-PEG5-OH  纯度: ≥98.0%

NH2-PEG5-OH 是一种 PROTAC linker,属于 PEG 类。NH2-PEG5-OH 可用于合成PROTAC分子。NH2-PEG5-OH 也是一种不可降解 (non-cleavable) 的含 5 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

NH2-PEG5-OH

NH2-PEG5-OH Chemical Structure

CAS No. : 34188-11-9

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Free Sample (0.1-0.5 mg)   Apply now  
100 mg ¥2000 In-stock
500 mg ¥4000 In-stock
1 g   询价  
5 g   询价  

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生物活性

NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC50 & Target

PEGs

 

Non-cleavable

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

237.29

Formula

C10H23NO5

CAS 号

34188-11-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL (421.43 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.2143 mL 21.0713 mL 42.1425 mL
5 mM 0.8429 mL 4.2143 mL 8.4285 mL
10 mM 0.4214 mL 2.1071 mL 4.2143 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.54 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.54 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.54 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.54 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.54 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.54 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.

    [2]. Nianhe Han, et al. Derivatives of dolastatin 10 and uses thereof. WO2016192527A1.

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Fmoc-Asp-NH2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Fmoc-Asp-NH2  纯度: 98.04%

Fmoc-Asp-NH2 是一种可以切割的 ADC linker,用于制备抗体偶联药物 (ADC)。

Fmoc-Asp-NH2

Fmoc-Asp-NH2 Chemical Structure

CAS No. : 200335-40-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
500 mg ¥1150 In-stock
1 g ¥1650 In-stock
2 g ¥2800 In-stock
5 g   询价  
10 g   询价  

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生物活性

Fmoc-Asp-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC50 & Target

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

354.36

Formula

C19H18N2O5

CAS 号

200335-40-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

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NH2-PEG5-C6-Cl

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

NH2-PEG5-C6-Cl 

NH2-PEG5-C6-Cl (K-7) 是一种 PEG 类 linker。NH2-PEG5-C6-Cl 可用于合成一系列化合物,它们通过自噬诱导细胞内分子降解。

NH2-PEG5-C6-Cl

NH2-PEG5-C6-Cl Chemical Structure

CAS No. : 1261238-22-5

规格 是否有货
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生物活性

NH2-PEG5-C6-Cl (K-7) is a linker which refers to the PEG composition. NH2-PEG5-C6-Cl can be used in the synthesis of a series of compounds that induce degradation of intracellular molecules by autophagy[1].

分子量

355.90

Formula

C16H34ClNO5

CAS 号

1261238-22-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Heterocyclic compound. WO2018143403A1.

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Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA 

Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA 是一种可降解的双 linker,含 3 个单元 PEG 和 4 个单元 PEG ,可用于合成抗体偶联药物 (ADC) 。Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA 还是一种 PROTAC linker。可用于合成 PROTAC 分子。

Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA

Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA is a double claevable 3-unit and 4-unit PEG linker for antibody-drug-conjugation (ADC). Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA also is a PROTAC linker that can be used in the synthesis of PROTACs.

IC50 & Target

Cleavable

 

PEGs

 

Alkyl/ether

 

分子量

1346.57

Formula

C66H99N13O17

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务