Mito-TRFS

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Mito-TRFS  纯度: 95.75%

Mito-TRFS 是首个off-on 探针，可用于活细胞中线粒体硫氧还蛋白还原酶 (TrxR2) 的呈像。

Mito-TRFS

Mito-TRFS Chemical Structure

CAS No. : 1859102-62-7

规格 价格 是否有货 数量
1 mg ￥2400 In-stock
5 mg ￥7200 In-stock
10 mg ￥11500 In-stock
50 mg   询价  
100 mg   询价  

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Mito-TRFS 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus

生物活性

Mito-TRFS, the first off-on probe, is used to image the mitochondrial thioredoxin reductase (TrxR2) in live cells[1].

体外研究
(In Vitro)

Mito-TRFS (10 μM) has the maximal absorption at ~375 nm in TE buffer (50 mM Tris-HCl and 1 mM EDTA, pH 7.4) at 37 °C[1].
Mito-TRFS itself has a strong emission at ~480 nm when excited at 375 nm in TE buffer (φ=0.34), but has weak emission when excited at 438 nm[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence[1].

Cell Line: HeLa cells.
Concentration: 1 μM.
Incubation Time: 2 h.
Result: Mito-TRFS is localized predominantly in the mitochondria of live cells.

分子量

820.70

Formula

C38H34IN2O5PS2
CAS 号

1859102-62-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. Yaping Liu, et al. A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson’s disease model. Chem Commun (Camb). 2016 Feb 7;52(11):2296-9.

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