E7766 diammonium salt

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E7766 diammonium salt  纯度: 99.73%

E7766 diammonium salt 是一种大环桥连 STING 激动剂,Kd 为 40 nM。E7766 diammonium salt 显示出强大的泛基因型和抗肿瘤活性。

E7766 diammonium salt

E7766 diammonium salt Chemical Structure

CAS No. : 2242635-03-4

规格 价格 是否有货 数量
1 mg ¥5800 In-stock
5 mg ¥16500 In-stock
10 mg ¥26500 In-stock
50 mg   询价  
100 mg   询价  

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E7766 diammonium salt 相关产品

相关化合物库:

  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Macrocyclic Compound Library

生物活性

E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities[1].

体外研究
(In Vitro)

E7766 diammonium salt inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC50 values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 diammonium salt in the subcutaneous tumor. E7766 diammonium salt is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

780.66

Formula

C24H32F2N12O8P2S2

CAS 号

2242635-03-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O : 45 mg/mL (57.64 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2810 mL 6.4048 mL 12.8097 mL
5 mM 0.2562 mL 1.2810 mL 2.5619 mL
10 mM 0.1281 mL 0.6405 mL 1.2810 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Dae-Shik Kim, et al. E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity. ChemMedChem. 2021 Jun 7;16(11):1740-1743.

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