甘露醇盐琼脂培养基(USP)(Mannitol Salt Agar)

发表于2024年4月22日由上海金畔生物科技有限公司

上海金畔生物科技有限公司可以定制生产国产培养基，可以访问官网了解更多产品信息。
甘露醇盐琼脂培养基(USP)(Mannitol Salt Agar)

：

英文名称：	Mannitol Salt Agar
产品货号：	JP4128-2
产品规格：	250g
190元
保质期：	三年
产品用途：	用于金黄色葡萄球菌选择性分离培养
备注：

产品介绍:

用途：用于金黄色葡萄球菌选择性分离培养

成分(g/L):

Pancreatic digest of casein/胰酶解酪蛋白	5.0
Peptic digest of animal tissue/动物组织胃酶消化物	5.0
Beef extract /牛肉浸粉	1.0
D-Mannitol /D-甘露醇	10.0
Sodium chloride/氯化钠	75.0
Agar/琼脂	15.0
Phenol red/酚红	0.025
pH值7.4±0.2	25℃

用法：

Suspend 111.0g/liter , heat to boiling for 1 min with shaking, autoclave at 121℃ for 15 min.

称取本品111.0g ,加入1000ml蒸馏水中,加热溶解并不停搅拌煮沸 1分钟，121℃高压灭菌 15分钟备用。

金黄色葡萄球菌在甘露醇盐琼脂培养基上的生长特征：

黄色菌落，菌落周围黄色

甘露醇盐琼脂培养基(USP)微生物灵敏度试验:

按标签用法制备培养基，接种以下质控菌株，放置30-35℃需氧培养18-72小时。
注：回收率计算时，用TSA琼脂做对照培养基。

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E7766 diammonium salt

发表于2024年3月4日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

E7766 diammonium salt 纯度: 99.73%

E7766 diammonium salt 是一种大环桥连 STING 激动剂，K_d 为 40 nM。E7766 diammonium salt 显示出强大的泛基因型和抗肿瘤活性。

E7766 diammonium salt Chemical Structure

CAS No. : 2242635-03-4

规格	价格	是否有货
1 mg	￥5800	In-stock
5 mg	￥16500	In-stock
10 mg	￥26500	In-stock
50 mg		询价
100 mg		询价

* Please select Quantity before adding items.

E7766 diammonium salt 相关产品

•相关化合物库:

Clinical Compound Library Plus
Bioactive Compound Library Plus
Macrocyclic Compound Library

生物活性

E7766 diammonium salt is a macrocycle-bridged STING agonist with a K_d of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities^[1].

体外研究
(In Vitro)

E7766 diammonium salt inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC₅₀ values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 diammonium salt in the subcutaneous tumor. E7766 diammonium salt is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

780.66

Formula

C₂₄H₃₂F₂N₁₂O₈P₂S₂

CAS 号

2242635-03-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

H₂O : 45 mg/mL (57.64 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.2810 mL	6.4048 mL	12.8097 mL
5 mM	0.2562 mL	1.2810 mL	2.5619 mL
10 mM	0.1281 mL	0.6405 mL	1.2810 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

参考文献

[1]. Dae-Shik Kim, et al. E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity. ChemMedChem. 2021 Jun 7;16(11):1740-1743.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pasireotide L-aspartate salt(Synonyms: 帕瑞肽天门冬氨酸盐; SOM230 L-aspartate)

发表于2024年2月22日由上海金畔生物科技有限公司

Pasireotide L-aspartate salt (Synonyms: 帕瑞肽天门冬氨酸盐; SOM230 L-aspartate) 纯度: 99.44%

Pasireotide (SOM230) L-aspartate salt 是一种长效的环己肽生长激素抑制素类似物，可以提高生长抑素受体的激动剂活性，对 sst1/2/3/4/5 的 pK_i 分别为 8.2/9.0/9.1/<7.0/9.9。Pasireotide L-aspartate salt 具有抗分泌、抗增殖和促凋亡活性。

Pasireotide L-aspartate salt Chemical Structure

CAS No. : 396091-77-3

规格	价格	是否有货
1 mg	￥2100	In-stock
5 mg	￥6900	In-stock
10 mg	￥11000	In-stock
50 mg		询价
100 mg		询价

* Please select Quantity before adding items.

Pasireotide L-aspartate salt 相关产品

•相关化合物库:

Drug Repurposing Compound Library Plus
FDA-Approved Drug Library Plus
Bioactive Compound Library Plus
Peptidomimetic Library
Macrocyclic Compound Library

生物活性

Pasireotide (SOM230) L-aspartate salt, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pK_i=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide L-aspartate salt exhibits antisecretory, antiproliferative, and proapoptotic activity^[1]^[2].

IC₅₀ & Target

pKi: 8.2 (sst1), 9.0 (sst2), 9.1 (sst3), <7.0 (sst4), 9.9 (sst5)^[1]

体外研究
(In Vitro)

Pasireotide L-aspartate salt exhibits unique high-affinity binding to human somatostatin receptors (subtypes sst1/2/3/4/5, pK_i=8.2/9.0/9.1/<7.0/9.9, respectively)^[1].
Pasireotide L-aspartate salt effectively inhibits the growth hormone releasing hormone (GHRH) induced growth hormone (GH) release in primary cultures of rat pituitary cells, with an IC₅₀ of 0.4 nM^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Pasireotide L-aspartate salt (160 mg/kg/mouth; s.c. for 4 months) significantly decreases the serum insulin, increases serum glucose, reduces the tumor size and increases apoptosis in Pdx1-Cre^[2].
Pasireotide L-aspartate salt (2-50 μg/kg; s.c. twice daily for 42 days) exerts the antinociceptive and antiinflammatory actions via the SSTR2 receptor in a mouse model of immune-mediated arthritis^[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	12 month-old conditional Men1 knockout mice with insulinoma^[2]
Dosage:	160 mg/kg/mouth
Administration:	S.c. every month for 4 months
Result:	Decreased the serum insulin from 1.060 μg/L to 0.3653 μg/L and increased the serum glucose from 4.246 mM to 7.122 mM. Significantly reduced the tumor size and increased apoptosis.

Clinical Trial

分子量

1180.31

Formula

C₆₂H₇₃N₁₁O₁₃

CAS 号

396091-77-3

中文名称

帕瑞肽天门冬氨酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 1 mg/mL (0.85 mM; Need ultrasonic)

参考文献

[1]. Lewis I, et, al. A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential. J Med Chem. 2003 Jun 5;46(12):2334-44.

[2]. Quinn TJ, et, al. Pasireotide (SOM230) is effective for the treatment of pancreatic neuroendocrine tumors (PNETs) in a multiple endocrine neoplasia type 1 (MEN1) conditional knockout mouse model. Surgery. 2012 Dec;152(6):1068-77.

[3]. Imhof AK, et, al. Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis. Arthritis Rheum. 2011 Aug;63(8):2352-62.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Transcrocetin meglumine salt(Synonyms: trans-Crocetin meglumine salt)

发表于2024年2月19日由上海金畔生物科技有限公司

Transcrocetin meglumine salt (Synonyms: trans-Crocetin meglumine salt) 纯度: 99.28%

Transcrocetin meglumine salt 从藏红花 (Crocus sativus L.) 中提取的，是一种高亲和力的 NMDA 受体拮抗剂。

Transcrocetin meglumine salt Chemical Structure

规格	价格	是否有货
Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in DMSO	￥2451	In-stock
5 mg	￥1550	In-stock
10 mg	￥2850	In-stock
25 mg	￥5800	In-stock
50 mg		询价
100 mg		询价

* Please select Quantity before adding items.

Transcrocetin meglumine salt 相关产品

•相关化合物库:

Natural Product Library Plus
Drug Repurposing Compound Library Plus
Clinical Compound Library Plus
Bioactive Compound Library Plus
Membrane Transporter/Ion Channel Compound Library
Neuronal Signaling Compound Library
Natural Product Library
Anti-Cancer Compound Library
Clinical Compound Library
Drug Repurposing Compound Library
Medicine Food Homology Compound Library
Terpenoids Library
Neurotransmitter Receptor Compound Library
Anti-Alzheimer’s Disease Compound Library
Neuroprotective Compound Library
Anti-Parkinson’s Disease Compound Library
Neurodegenerative Disease-related Compound Library
Food-Sourced Compound Library

生物活性

Transcrocetin meglumine salt, extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity.

IC₅₀ & Target

NMDA receptor^[1]

体外研究
(In Vitro)

Transcrocetin (trans-Crocetin), a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron.To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 µM) reveal no negative significant changes in cellular viability. Transcrocetin at 10 µM level does not change viability while higher concentrations (40-160 µM) reduces significantly cellular viability^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

718.83

Formula

C₃₄H₅₈N₂O₁₄

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 8.33 mg/mL (11.59 mM; ultrasonic and warming and heat to 66°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3911 mL	6.9557 mL	13.9115 mL
5 mM	0.2782 mL	1.3911 mL	2.7823 mL
10 mM	0.1391 mL	0.6956 mL	1.3911 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: 0.83 mg/mL (1.15 mM); Suspended solution; Need ultrasonic

此方案可获得 0.83 mg/mL (1.15 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 0.83 mg/mL (1.15 mM); Clear solution

此方案可获得 ≥ 0.83 mg/mL (1.15 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Lautenschläger M, et al. Intestinal formation of trans-Crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier. Phytomedicine. 2015 Jan 15;22(1):36-44.

Cell Assay ^[1]	Cytotoxicity of test compounds is determined by MTT assay using Caco-2 cells in 96 well plates at a density of 20.000 cells per well in 200 µl FBS-free medium, grown for 96 h and followed by 24 h contact time with the test compounds (100 µL of serum-free media containing SE 0.5, 1, and 2 mg/mL; trans-crocin-1 250, 500, and 1000 µM; Transcrocetin 10, 40, 80, and 160 µM) and incubation at 37°C/5% CO₂. The incubation solutions are aspirated, each well is washed twice with 150 µL of PBS and 50 µL of MTT solution are added (2.5 mg/mL in PBS). Supernatants are discarded and the formed formazan is dissolved in 50 µL of DMSO. The absorption of the resulting solution is determined at λ=492 nm against reference wavelength λ=690 nm^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Lautenschläger M, et al. Intestinal formation of trans-Crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier. Phytomedicine. 2015 Jan 15;22(1):36-44.

Cell Assay
^[1]

Cytotoxicity of test compounds is determined by MTT assay using Caco-2 cells in 96 well plates at a density of 20.000 cells per well in 200 µl FBS-free medium, grown for 96 h and followed by 24 h contact time with the test compounds (100 µL of serum-free media containing SE 0.5, 1, and 2 mg/mL; trans-crocin-1 250, 500, and 1000 µM; Transcrocetin 10, 40, 80, and 160 µM) and incubation at 37°C/5% CO₂. The incubation solutions are aspirated, each well is washed twice with 150 µL of PBS and 50 µL of MTT solution are added (2.5 mg/mL in PBS). Supernatants are discarded and the formed formazan is dissolved in 50 µL of DMSO. The absorption of the resulting solution is determined at λ=492 nm against reference wavelength λ=690 nm^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Lautenschläger M, et al. Intestinal formation of trans-Crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier. Phytomedicine. 2015 Jan 15;22(1):36-44.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Batimastat sodium salt(Synonyms: BB-94 sodium salt)

发表于2023年11月15日由上海金畔生物科技有限公司

Batimastat sodium salt (Synonyms: BB-94 sodium salt)

Batimastat(BB-94)钠是广谱的基质金属蛋白酶（MMPs）抑制剂，对MMP-1/2/3/7/9的IC50分别为3/4/20/6/4 nM。

Batimastat sodium salt Chemical Structure

CAS No. : 130464-84-5

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Batimastat sodium salt 的其他形式现货产品:

Batimastat

生物活性	Batimastat sodium salt is a potent broad spectrum MMP inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.
IC₅₀ & Target	IC50: 3 nM (MMP-1), 4 nM (MMP-2), 4 nM (MMP-9), 6 nM (MMP-7), 20 nM (MMP-3)^[1]
体外研究 (In Vitro)	Batimastat (BB-94) is a potent matrix metalloproteinase inhibitor, exhibits an unexpected mode of binding. Batimastat inhibits gelatinases A and B with IC₅₀ values of 4 nM and 10 nM, respectively. The IC₅₀ with the structurally similar collagenase Ht-d is 6 nM, which is comparable with values for MMP-1 (3 nM), MMP-8 (10 nM), and MMP-3 (20 nM)^[2]. CD30 shedding from the cell line Karpas299 can effectively be blocked by the hydroxamic acidbased metalloproteinase inhibitor Batimastat (BB-94, IC₅₀=230 nM)^[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	Intraperitoneal administration of Batimastat (BB-94) effectively blocks growth of human ovarian carcinoma xenografts and murine melanoma metastasis and delays the growth of primary tumors in an orthotopic model of human breast cancer without cytotoxicity and without affecting mRNA levels^[2]. Batimastat (BB-94) is a synthetic matrix metalloproteinase inhibitor that has shown antineoplastic and antiangiogenic activity in various tumor models. Treatment with Batimastat (60 mg/kg i.p. every other day, for a total of eight injections) concomitantly with Cisplatin (4 mg/kg i.v., every 7 days for a total of three injections) completely prevents growth and spread of both xenografts, and all animals are alive and healthy on day 200^[4]. Kaplan-Meier analysis of survival (at 48 h) shows that animals treated with Batimastat (BB-94) have increased survival (95.2%) in comparison with controls (75%), and differences are almost statistically significant (p=0.064)^[5]. Matrix density is analyzed in saline- or Batimastat (40 mg/kg)-pretreated animals 4 h after E₂ administration, the time point at which collagen density is observed to be at its lowest after hormone treatment^[6]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	499.62
Formula	C₂₃H₃₀N₃NaO₄S₂
CAS 号	130464-84-5
中文名称	巴马司他纳盐
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Yin Z, et al. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E55-70. [2]. Botos I, et al. Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54. [3]. Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002 Mar 10;98(2):210-5. [4]. Giavazzi R, et al. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts. Clin Cancer Res. 1998 Apr;4(4):985-92. [5]. Ricci S, et al. Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC Infect Dis. 2014 Dec 31;14:726. [6]. Russo LA, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009 Nov 4;7:124.

Animal Administration ^[5]^[6]	Mice^[5] Six-weeks-old female BALB/c mice are used. Mice are treated i.p. with Batimastat (BB-94, 50 mg/kg) 1 h before and 24 h post-infection. Batimastat is suspended at 50 mg/mL in DMSO and stored frozen at -20°C. Prior to use, it is diluted 20-fold in phosphate buffered saline (PBS), and 500 μL are injected into animals. Control mice are injected with 500 μL of 5% DMSO in PBS. Animals are sacrificed 48 h after i.c. challenge. Rats^[6] Female Sprague-Dawley rats are administered a single physiological dose of E₂ (40 μg/kg in a 0.9% NaCl, 0.4% EtOH vehicle) by intraperitoneal (i.p.) injection at the indicated time intervals prior to tissue collection at necropsy. This in vivo dose level of E₂ has been shown to induce changes in uterine wet weight, tissue architecture, and gene expression characteristic of estrogen receptor activation. For all other experiments, animals are i.p. administered a single 40 μg/kg bolus of E₂ 4 h prior to tissue harvest, while control animals receive vehicle only in all studies. Batimastat is administered i.p. at a dose level (40 mg/kg in a 1× PBS, 0.1% Tween-20 vehicle) shown to be effective at inhibiting MMPs in vivo 4 h prior to E₂ or saline control. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Yin Z, et al. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E55-70. [2]. Botos I, et al. Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54. [3]. Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002 Mar 10;98(2):210-5. [4]. Giavazzi R, et al. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts. Clin Cancer Res. 1998 Apr;4(4):985-92. [5]. Ricci S, et al. Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC Infect Dis. 2014 Dec 31;14:726. [6]. Russo LA, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009 Nov 4;7:124.

Animal Administration
^[5]^[6]

Mice^[5]
Six-weeks-old female BALB/c mice are used. Mice are treated i.p. with Batimastat (BB-94, 50 mg/kg) 1 h before and 24 h post-infection. Batimastat is suspended at 50 mg/mL in DMSO and stored frozen at -20°C. Prior to use, it is diluted 20-fold in phosphate buffered saline (PBS), and 500 μL are injected into animals. Control mice are injected with 500 μL of 5% DMSO in PBS. Animals are sacrificed 48 h after i.c. challenge.
Rats^[6]
Female Sprague-Dawley rats are administered a single physiological dose of E₂ (40 μg/kg in a 0.9% NaCl, 0.4% EtOH vehicle) by intraperitoneal (i.p.) injection at the indicated time intervals prior to tissue collection at necropsy. This in vivo dose level of E₂ has been shown to induce changes in uterine wet weight, tissue architecture, and gene expression characteristic of estrogen receptor activation. For all other experiments, animals are i.p. administered a single 40 μg/kg bolus of E₂ 4 h prior to tissue harvest, while control animals receive vehicle only in all studies. Batimastat is administered i.p. at a dose level (40 mg/kg in a 1× PBS, 0.1% Tween-20 vehicle) shown to be effective at inhibiting MMPs in vivo 4 h prior to E₂ or saline control.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Yin Z, et al. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E55-70.

[2]. Botos I, et al. Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54.

[3]. Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002 Mar 10;98(2):210-5.

[4]. Giavazzi R, et al. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts. Clin Cancer Res. 1998 Apr;4(4):985-92.

[5]. Ricci S, et al. Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC Infect Dis. 2014 Dec 31;14:726.

[6]. Russo LA, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009 Nov 4;7:124.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Batimastat sodium salt(Synonyms: BB-94 sodium salt)

发表于2023年11月15日由上海金畔生物科技有限公司

Batimastat sodium salt (Synonyms: BB-94 sodium salt)

Batimastat(BB-94)钠是广谱的基质金属蛋白酶（MMPs）抑制剂，对MMP-1/2/3/7/9的IC50分别为3/4/20/6/4 nM。

Batimastat sodium salt Chemical Structure

CAS No. : 130464-84-5

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Batimastat sodium salt 的其他形式现货产品:

Batimastat

生物活性	Batimastat sodium salt is a potent broad spectrum MMP inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.
IC₅₀ & Target	IC50: 3 nM (MMP-1), 4 nM (MMP-2), 4 nM (MMP-9), 6 nM (MMP-7), 20 nM (MMP-3)^[1]
体外研究 (In Vitro)	Batimastat (BB-94) is a potent matrix metalloproteinase inhibitor, exhibits an unexpected mode of binding. Batimastat inhibits gelatinases A and B with IC₅₀ values of 4 nM and 10 nM, respectively. The IC₅₀ with the structurally similar collagenase Ht-d is 6 nM, which is comparable with values for MMP-1 (3 nM), MMP-8 (10 nM), and MMP-3 (20 nM)^[2]. CD30 shedding from the cell line Karpas299 can effectively be blocked by the hydroxamic acidbased metalloproteinase inhibitor Batimastat (BB-94, IC₅₀=230 nM)^[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	Intraperitoneal administration of Batimastat (BB-94) effectively blocks growth of human ovarian carcinoma xenografts and murine melanoma metastasis and delays the growth of primary tumors in an orthotopic model of human breast cancer without cytotoxicity and without affecting mRNA levels^[2]. Batimastat (BB-94) is a synthetic matrix metalloproteinase inhibitor that has shown antineoplastic and antiangiogenic activity in various tumor models. Treatment with Batimastat (60 mg/kg i.p. every other day, for a total of eight injections) concomitantly with Cisplatin (4 mg/kg i.v., every 7 days for a total of three injections) completely prevents growth and spread of both xenografts, and all animals are alive and healthy on day 200^[4]. Kaplan-Meier analysis of survival (at 48 h) shows that animals treated with Batimastat (BB-94) have increased survival (95.2%) in comparison with controls (75%), and differences are almost statistically significant (p=0.064)^[5]. Matrix density is analyzed in saline- or Batimastat (40 mg/kg)-pretreated animals 4 h after E₂ administration, the time point at which collagen density is observed to be at its lowest after hormone treatment^[6]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	499.62
Formula	C₂₃H₃₀N₃NaO₄S₂
CAS 号	130464-84-5
中文名称	巴马司他纳盐
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Yin Z, et al. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E55-70. [2]. Botos I, et al. Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54. [3]. Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002 Mar 10;98(2):210-5. [4]. Giavazzi R, et al. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts. Clin Cancer Res. 1998 Apr;4(4):985-92. [5]. Ricci S, et al. Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC Infect Dis. 2014 Dec 31;14:726. [6]. Russo LA, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009 Nov 4;7:124.

Animal Administration ^[5]^[6]	Mice^[5] Six-weeks-old female BALB/c mice are used. Mice are treated i.p. with Batimastat (BB-94, 50 mg/kg) 1 h before and 24 h post-infection. Batimastat is suspended at 50 mg/mL in DMSO and stored frozen at -20°C. Prior to use, it is diluted 20-fold in phosphate buffered saline (PBS), and 500 μL are injected into animals. Control mice are injected with 500 μL of 5% DMSO in PBS. Animals are sacrificed 48 h after i.c. challenge. Rats^[6] Female Sprague-Dawley rats are administered a single physiological dose of E₂ (40 μg/kg in a 0.9% NaCl, 0.4% EtOH vehicle) by intraperitoneal (i.p.) injection at the indicated time intervals prior to tissue collection at necropsy. This in vivo dose level of E₂ has been shown to induce changes in uterine wet weight, tissue architecture, and gene expression characteristic of estrogen receptor activation. For all other experiments, animals are i.p. administered a single 40 μg/kg bolus of E₂ 4 h prior to tissue harvest, while control animals receive vehicle only in all studies. Batimastat is administered i.p. at a dose level (40 mg/kg in a 1× PBS, 0.1% Tween-20 vehicle) shown to be effective at inhibiting MMPs in vivo 4 h prior to E₂ or saline control. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Yin Z, et al. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E55-70. [2]. Botos I, et al. Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54. [3]. Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002 Mar 10;98(2):210-5. [4]. Giavazzi R, et al. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts. Clin Cancer Res. 1998 Apr;4(4):985-92. [5]. Ricci S, et al. Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC Infect Dis. 2014 Dec 31;14:726. [6]. Russo LA, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009 Nov 4;7:124.

Animal Administration
^[5]^[6]

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Yin Z, et al. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E55-70.

[2]. Botos I, et al. Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54.

[3]. Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002 Mar 10;98(2):210-5.

[4]. Giavazzi R, et al. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts. Clin Cancer Res. 1998 Apr;4(4):985-92.

[5]. Ricci S, et al. Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC Infect Dis. 2014 Dec 31;14:726.

[6]. Russo LA, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009 Nov 4;7:124.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Batimastat sodium salt(Synonyms: BB-94 sodium salt)

发表于2023年11月15日由上海金畔生物科技有限公司

Batimastat sodium salt (Synonyms: BB-94 sodium salt)

Batimastat(BB-94)钠是广谱的基质金属蛋白酶（MMPs）抑制剂，对MMP-1/2/3/7/9的IC50分别为3/4/20/6/4 nM。

Batimastat sodium salt Chemical Structure

CAS No. : 130464-84-5

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Batimastat sodium salt 的其他形式现货产品:

Batimastat

生物活性	Batimastat sodium salt is a potent broad spectrum MMP inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.
IC₅₀ & Target	IC50: 3 nM (MMP-1), 4 nM (MMP-2), 4 nM (MMP-9), 6 nM (MMP-7), 20 nM (MMP-3)^[1]
体外研究 (In Vitro)	Batimastat (BB-94) is a potent matrix metalloproteinase inhibitor, exhibits an unexpected mode of binding. Batimastat inhibits gelatinases A and B with IC₅₀ values of 4 nM and 10 nM, respectively. The IC₅₀ with the structurally similar collagenase Ht-d is 6 nM, which is comparable with values for MMP-1 (3 nM), MMP-8 (10 nM), and MMP-3 (20 nM)^[2]. CD30 shedding from the cell line Karpas299 can effectively be blocked by the hydroxamic acidbased metalloproteinase inhibitor Batimastat (BB-94, IC₅₀=230 nM)^[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	Intraperitoneal administration of Batimastat (BB-94) effectively blocks growth of human ovarian carcinoma xenografts and murine melanoma metastasis and delays the growth of primary tumors in an orthotopic model of human breast cancer without cytotoxicity and without affecting mRNA levels^[2]. Batimastat (BB-94) is a synthetic matrix metalloproteinase inhibitor that has shown antineoplastic and antiangiogenic activity in various tumor models. Treatment with Batimastat (60 mg/kg i.p. every other day, for a total of eight injections) concomitantly with Cisplatin (4 mg/kg i.v., every 7 days for a total of three injections) completely prevents growth and spread of both xenografts, and all animals are alive and healthy on day 200^[4]. Kaplan-Meier analysis of survival (at 48 h) shows that animals treated with Batimastat (BB-94) have increased survival (95.2%) in comparison with controls (75%), and differences are almost statistically significant (p=0.064)^[5]. Matrix density is analyzed in saline- or Batimastat (40 mg/kg)-pretreated animals 4 h after E₂ administration, the time point at which collagen density is observed to be at its lowest after hormone treatment^[6]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	499.62
Formula	C₂₃H₃₀N₃NaO₄S₂
CAS 号	130464-84-5
中文名称	巴马司他纳盐
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Yin Z, et al. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E55-70. [2]. Botos I, et al. Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54. [3]. Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002 Mar 10;98(2):210-5. [4]. Giavazzi R, et al. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts. Clin Cancer Res. 1998 Apr;4(4):985-92. [5]. Ricci S, et al. Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC Infect Dis. 2014 Dec 31;14:726. [6]. Russo LA, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009 Nov 4;7:124.

Animal Administration ^[5]^[6]	Mice^[5] Six-weeks-old female BALB/c mice are used. Mice are treated i.p. with Batimastat (BB-94, 50 mg/kg) 1 h before and 24 h post-infection. Batimastat is suspended at 50 mg/mL in DMSO and stored frozen at -20°C. Prior to use, it is diluted 20-fold in phosphate buffered saline (PBS), and 500 μL are injected into animals. Control mice are injected with 500 μL of 5% DMSO in PBS. Animals are sacrificed 48 h after i.c. challenge. Rats^[6] Female Sprague-Dawley rats are administered a single physiological dose of E₂ (40 μg/kg in a 0.9% NaCl, 0.4% EtOH vehicle) by intraperitoneal (i.p.) injection at the indicated time intervals prior to tissue collection at necropsy. This in vivo dose level of E₂ has been shown to induce changes in uterine wet weight, tissue architecture, and gene expression characteristic of estrogen receptor activation. For all other experiments, animals are i.p. administered a single 40 μg/kg bolus of E₂ 4 h prior to tissue harvest, while control animals receive vehicle only in all studies. Batimastat is administered i.p. at a dose level (40 mg/kg in a 1× PBS, 0.1% Tween-20 vehicle) shown to be effective at inhibiting MMPs in vivo 4 h prior to E₂ or saline control. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Yin Z, et al. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E55-70. [2]. Botos I, et al. Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54. [3]. Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002 Mar 10;98(2):210-5. [4]. Giavazzi R, et al. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts. Clin Cancer Res. 1998 Apr;4(4):985-92. [5]. Ricci S, et al. Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC Infect Dis. 2014 Dec 31;14:726. [6]. Russo LA, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009 Nov 4;7:124.

Animal Administration
^[5]^[6]

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Yin Z, et al. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E55-70.

[2]. Botos I, et al. Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54.

[3]. Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002 Mar 10;98(2):210-5.

[4]. Giavazzi R, et al. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts. Clin Cancer Res. 1998 Apr;4(4):985-92.

[5]. Ricci S, et al. Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC Infect Dis. 2014 Dec 31;14:726.

[6]. Russo LA, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009 Nov 4;7:124.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Adapalene sodium salt(Synonyms: 阿达帕林钠; CD 271 sodium salt)

发表于2023年11月15日由上海金畔生物科技有限公司

Adapalene sodium salt (Synonyms: 阿达帕林钠; CD 271 sodium salt)

Adapalene (CD271) sodium salt 是第三代合成类视黄醇，局部应用于痤疮。Adapalene sodium salt 是一种有效的 RAR 激动剂，对 RARβ、RARγ、RARα 的 AC₅₀ 值分别为 2.3 nM、9.3 nM 和 22 nM。Adapalene sodium salt 还以非竞争性方式抑制 GOT1 的酶活性。Adapalene sodium salt 具有抗肿瘤活性。

Adapalene sodium salt Chemical Structure

CAS No. : 911110-93-5

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Adapalene sodium salt 的其他形式现货产品:

Adapalene

生物活性

Adapalene (CD271) sodium salt, a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene sodium salt is a potent RAR agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene sodium salt also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene sodium salt exhibits anti-tumor activity^[1]^[2]^[3].

IC₅₀ & Target

AC50: 2.3 nM (RARβ), 9.3 nM (RARγ), and 22 nM (RARα)^[1]

体外研究
(In Vitro)

Adapalene sodium salt (1-200 μM; 24 h) inhibits the viability of ES-2, HOV-7, MCF-7 , Hela, SW1990, HT1080, and MM-468 cells, with IC₅₀s of 10.36 μM, 10.81 μM, 12.00 μM, 19.08 μM, 19.52 μM, 21.70 μM, and 31.47 μM, respectively^[2].
Adapalene sodium salt (10-40 μM; 24 h) induces ES-2 cells apoptosis and inhibits proliferation in vitro^[2].
Adapalene sodium salt (3-30 μM; 6-24 h) significantly increases the G1-phase population in LoVo or DLD1 cells^[3].
Adapalene sodium salt (1-200 μM) inhibits GOT1 activity, with an IC₅₀ of 21.79 μM^[2].
Adapalene sodium salt (10^-6-10^-3 nM) inhibits the expression of plasma membrane-associated enzyme transglutaminase Type I, with an IC₅₀ of 2.5 nM^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	Pancreatic cancer (SW1990, Aspc-1), breast cancer (mm-231, mm-468, MCF-7), liver cancer (Hep3B), cervical cancer (Hela), ovarian cancer (HOV-7, ES-2), normal cells (CHO, L929)
Concentration:	1-200 μM
Incubation Time:	24 hours
Result:	Inhibited the viability of cancer cells with higher GOT1 protein expression.

Apoptosis Analysis^[2]

Cell Line:	ES-2 cells
Concentration:	10, 20, 40 μM
Incubation Time:	24 hours
Result:	Showed a significant increase in apoptosis compared with the control group. Down regulated the expression of anti-apoptotic protein Bcl-2 and PARP.

Cell Cycle Analysis^[3]

Cell Line:	LoVo or DLD1 cells
Concentration:	3, 10, 30 μM
Incubation Time:	6, 12, 24 hours
Result:	Caused cell cycle arrest in G1 phase in a dose- and time-dependent manner.

体内研究
(In Vivo)

Adapalene sodium salt (15-100 mg/kg; p.o. daily for 21 days) inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice^[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/C nude mice (15 g, 4-5 weeks) were injected with DLD1 cells^[3]
Dosage:	15, 20, 65, 100 mg/kg
Administration:	P.o. daily for 21 days
Result:	Significantly reduced tumor weight and volume.

Clinical Trial

分子量

434.50

Formula

C₂₈H₂₇NaO₃

CAS 号

911110-93-5

中文名称

阿达帕林钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Shroot B, et, al. Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103.

[2]. Wang Q, et, al. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorg Chem. 2019 Dec;93:103315.

[3]. Shi XN, et, al. Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. Mol Med Rep. 2015 Nov;12(5):6501-8.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Adapalene sodium salt(Synonyms: 阿达帕林钠; CD 271 sodium salt)

发表于2023年11月15日由上海金畔生物科技有限公司

Adapalene sodium salt (Synonyms: 阿达帕林钠; CD 271 sodium salt)

Adapalene sodium salt Chemical Structure

CAS No. : 911110-93-5

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Adapalene sodium salt 的其他形式现货产品:

Adapalene

生物活性

IC₅₀ & Target

AC50: 2.3 nM (RARβ), 9.3 nM (RARγ), and 22 nM (RARα)^[1]

体外研究
(In Vitro)

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	Pancreatic cancer (SW1990, Aspc-1), breast cancer (mm-231, mm-468, MCF-7), liver cancer (Hep3B), cervical cancer (Hela), ovarian cancer (HOV-7, ES-2), normal cells (CHO, L929)
Concentration:	1-200 μM
Incubation Time:	24 hours
Result:	Inhibited the viability of cancer cells with higher GOT1 protein expression.

Apoptosis Analysis^[2]

Cell Line:	ES-2 cells
Concentration:	10, 20, 40 μM
Incubation Time:	24 hours
Result:	Showed a significant increase in apoptosis compared with the control group. Down regulated the expression of anti-apoptotic protein Bcl-2 and PARP.

Cell Cycle Analysis^[3]

Cell Line:	LoVo or DLD1 cells
Concentration:	3, 10, 30 μM
Incubation Time:	6, 12, 24 hours
Result:	Caused cell cycle arrest in G1 phase in a dose- and time-dependent manner.

体内研究
(In Vivo)

Adapalene sodium salt (15-100 mg/kg; p.o. daily for 21 days) inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice^[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/C nude mice (15 g, 4-5 weeks) were injected with DLD1 cells^[3]
Dosage:	15, 20, 65, 100 mg/kg
Administration:	P.o. daily for 21 days
Result:	Significantly reduced tumor weight and volume.

Clinical Trial

分子量

434.50

Formula

C₂₈H₂₇NaO₃

CAS 号

911110-93-5

中文名称

阿达帕林钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Shroot B, et, al. Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103.

[2]. Wang Q, et, al. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorg Chem. 2019 Dec;93:103315.

[3]. Shi XN, et, al. Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. Mol Med Rep. 2015 Nov;12(5):6501-8.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Adapalene sodium salt(Synonyms: 阿达帕林钠; CD 271 sodium salt)

发表于2023年11月15日由上海金畔生物科技有限公司

Adapalene sodium salt (Synonyms: 阿达帕林钠; CD 271 sodium salt)

Adapalene sodium salt Chemical Structure

CAS No. : 911110-93-5

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Adapalene sodium salt 的其他形式现货产品:

Adapalene

生物活性

IC₅₀ & Target

AC50: 2.3 nM (RARβ), 9.3 nM (RARγ), and 22 nM (RARα)^[1]

体外研究
(In Vitro)

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	Pancreatic cancer (SW1990, Aspc-1), breast cancer (mm-231, mm-468, MCF-7), liver cancer (Hep3B), cervical cancer (Hela), ovarian cancer (HOV-7, ES-2), normal cells (CHO, L929)
Concentration:	1-200 μM
Incubation Time:	24 hours
Result:	Inhibited the viability of cancer cells with higher GOT1 protein expression.

Apoptosis Analysis^[2]

Cell Line:	ES-2 cells
Concentration:	10, 20, 40 μM
Incubation Time:	24 hours
Result:	Showed a significant increase in apoptosis compared with the control group. Down regulated the expression of anti-apoptotic protein Bcl-2 and PARP.

Cell Cycle Analysis^[3]

Cell Line:	LoVo or DLD1 cells
Concentration:	3, 10, 30 μM
Incubation Time:	6, 12, 24 hours
Result:	Caused cell cycle arrest in G1 phase in a dose- and time-dependent manner.

体内研究
(In Vivo)

Adapalene sodium salt (15-100 mg/kg; p.o. daily for 21 days) inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice^[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/C nude mice (15 g, 4-5 weeks) were injected with DLD1 cells^[3]
Dosage:	15, 20, 65, 100 mg/kg
Administration:	P.o. daily for 21 days
Result:	Significantly reduced tumor weight and volume.

Clinical Trial

分子量

434.50

Formula

C₂₈H₂₇NaO₃

CAS 号

911110-93-5

中文名称

阿达帕林钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Shroot B, et, al. Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103.

[2]. Wang Q, et, al. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorg Chem. 2019 Dec;93:103315.

[3]. Shi XN, et, al. Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. Mol Med Rep. 2015 Nov;12(5):6501-8.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Esomeprazole magnesium salt(Synonyms: (S)-Omeprazole magnesium salt; (-)-Omeprazole magnesium salt)

发表于2023年11月15日由上海金畔生物科技有限公司

Esomeprazole magnesium salt (Synonyms: (S)-Omeprazole magnesium salt; (-)-Omeprazole magnesium salt)

Esomeprazole magnesium salt ((S)-Omeprazole magnesium salt) 是一种有效的具有口服活性质子泵抑制剂，可通过抑制胃壁细胞中的 H⁺, K⁺-ATPase 来降低酸分泌，并可用于胃食管反流疾病的研究。

Esomeprazole magnesium salt Chemical Structure

CAS No. : 1198768-91-0

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Esomeprazole magnesium salt 的其他形式现货产品:

Esomeprazole magnesium trihydrate Esomeprazole sodium Esomeprazole magnesium

生物活性

Esomeprazole magnesium salt ((S)-Omeprazole magnesium salt) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H⁺, K⁺-ATPase in gastric parietal cells. Esomeprazole magnesium salt has the potential for symptomatic gastroesophageal reflux disease research^[1]^[2]^[3].

IC₅₀ & Target

H⁺, K⁺-ATPase^[1]^[2]

体外研究
(In Vitro)

Esomeprazole (25-100 µM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-468 cells
Concentration:	25 µM, 50 µM, 75 µM, 100 µM
Incubation Time:	20 hours
Result:	Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.

体内研究
(In Vivo)

Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis^[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury^[2]
Dosage:	30 mg/kg, 300 mg/kg
Administration:	Oral gavage; daily; for 19 or 11 days
Result:	Significantly inhibited the progression of fibrosis throughout the lungs of the animals.

Clinical Trial

分子量

369.72

Formula

C₁₇H₂₁MgN₃O₃S

CAS 号

1198768-91-0

中文名称

埃索美拉唑镁盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17(3):439-46.

[2]. Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16.

[3]. Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Esomeprazole magnesium salt(Synonyms: (S)-Omeprazole magnesium salt; (-)-Omeprazole magnesium salt)

发表于2023年11月15日由上海金畔生物科技有限公司

Esomeprazole magnesium salt (Synonyms: (S)-Omeprazole magnesium salt; (-)-Omeprazole magnesium salt)

Esomeprazole magnesium salt Chemical Structure

CAS No. : 1198768-91-0

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Esomeprazole magnesium salt 的其他形式现货产品:

Esomeprazole magnesium trihydrate Esomeprazole sodium Esomeprazole magnesium

生物活性

IC₅₀ & Target

H⁺, K⁺-ATPase^[1]^[2]

体外研究
(In Vitro)

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-468 cells
Concentration:	25 µM, 50 µM, 75 µM, 100 µM
Incubation Time:	20 hours
Result:	Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.

体内研究
(In Vivo)

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury^[2]
Dosage:	30 mg/kg, 300 mg/kg
Administration:	Oral gavage; daily; for 19 or 11 days
Result:	Significantly inhibited the progression of fibrosis throughout the lungs of the animals.

Clinical Trial

分子量

369.72

Formula

C₁₇H₂₁MgN₃O₃S

CAS 号

1198768-91-0

中文名称

埃索美拉唑镁盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17(3):439-46.

[2]. Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16.

[3]. Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Esomeprazole magnesium salt(Synonyms: (S)-Omeprazole magnesium salt; (-)-Omeprazole magnesium salt)

发表于2023年11月15日由上海金畔生物科技有限公司

Esomeprazole magnesium salt (Synonyms: (S)-Omeprazole magnesium salt; (-)-Omeprazole magnesium salt)

Esomeprazole magnesium salt Chemical Structure

CAS No. : 1198768-91-0

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Esomeprazole magnesium salt 的其他形式现货产品:

Esomeprazole magnesium trihydrate Esomeprazole sodium Esomeprazole magnesium

生物活性

IC₅₀ & Target

H⁺, K⁺-ATPase^[1]^[2]

体外研究
(In Vitro)

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-468 cells
Concentration:	25 µM, 50 µM, 75 µM, 100 µM
Incubation Time:	20 hours
Result:	Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.

体内研究
(In Vivo)

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury^[2]
Dosage:	30 mg/kg, 300 mg/kg
Administration:	Oral gavage; daily; for 19 or 11 days
Result:	Significantly inhibited the progression of fibrosis throughout the lungs of the animals.

Clinical Trial

分子量

369.72

Formula

C₁₇H₂₁MgN₃O₃S

CAS 号

1198768-91-0

中文名称

埃索美拉唑镁盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17(3):439-46.

[2]. Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16.

[3]. Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Esomeprazole potassium salt(Synonyms: (S)-Omeprazole potassium salt; (-)-Omeprazole potassium salt)

发表于2023年11月15日由上海金畔生物科技有限公司

Esomeprazole potassium salt (Synonyms: (S)-Omeprazole potassium salt; (-)-Omeprazole potassium salt)

Esomeprazole potassium salt ((S)-Omeprazole potassium salt) 是一种有效的具有口服活性质子泵抑制剂，可通过抑制胃壁细胞中的 H⁺, K⁺-ATPase 来降低酸分泌，并可用于胃食管反流疾病的研究。

Esomeprazole potassium salt Chemical Structure

CAS No. : 161796-84-5

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Esomeprazole potassium salt 的其他形式现货产品:

Esomeprazole magnesium trihydrate Esomeprazole sodium Esomeprazole magnesium

生物活性

Esomeprazole potassium salt ((S)-Omeprazole potassium salt) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H⁺, K⁺-ATPase in gastric parietal cells. Esomeprazole potassium salt has the potential for symptomatic gastroesophageal reflux disease research^[1]^[2]^[3].

IC₅₀ & Target

H⁺, K⁺-ATPase^[1]^[2]

体外研究
(In Vitro)

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-468 cells
Concentration:	25 µM, 50 µM, 75 µM, 100 µM
Incubation Time:	20 hours
Result:	Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.

体内研究
(In Vivo)

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury^[2]
Dosage:	30 mg/kg, 300 mg/kg
Administration:	Oral gavage; daily; for 19 or 11 days
Result:	Significantly inhibited the progression of fibrosis throughout the lungs of the animals.

Clinical Trial

分子量

383.51

Formula

C₁₇H₁₈KN₃O₃S

CAS 号

161796-84-5

中文名称

埃索美拉唑钾盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17(3):439-46.

[2]. Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16.

[3]. Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Esomeprazole potassium salt(Synonyms: (S)-Omeprazole potassium salt; (-)-Omeprazole potassium salt)

发表于2023年11月15日由上海金畔生物科技有限公司

Esomeprazole potassium salt (Synonyms: (S)-Omeprazole potassium salt; (-)-Omeprazole potassium salt)

Esomeprazole potassium salt Chemical Structure

CAS No. : 161796-84-5

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Esomeprazole potassium salt 的其他形式现货产品:

Esomeprazole magnesium trihydrate Esomeprazole sodium Esomeprazole magnesium

生物活性

IC₅₀ & Target

H⁺, K⁺-ATPase^[1]^[2]

体外研究
(In Vitro)

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-468 cells
Concentration:	25 µM, 50 µM, 75 µM, 100 µM
Incubation Time:	20 hours
Result:	Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.

体内研究
(In Vivo)

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury^[2]
Dosage:	30 mg/kg, 300 mg/kg
Administration:	Oral gavage; daily; for 19 or 11 days
Result:	Significantly inhibited the progression of fibrosis throughout the lungs of the animals.

Clinical Trial

分子量

383.51

Formula

C₁₇H₁₈KN₃O₃S

CAS 号

161796-84-5

中文名称

埃索美拉唑钾盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17(3):439-46.

[2]. Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16.

[3]. Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Esomeprazole potassium salt(Synonyms: (S)-Omeprazole potassium salt; (-)-Omeprazole potassium salt)

发表于2023年11月15日由上海金畔生物科技有限公司

Esomeprazole potassium salt (Synonyms: (S)-Omeprazole potassium salt; (-)-Omeprazole potassium salt)

Esomeprazole potassium salt Chemical Structure

CAS No. : 161796-84-5

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Esomeprazole potassium salt 的其他形式现货产品:

Esomeprazole magnesium trihydrate Esomeprazole sodium Esomeprazole magnesium

生物活性

IC₅₀ & Target

H⁺, K⁺-ATPase^[1]^[2]

体外研究
(In Vitro)

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-468 cells
Concentration:	25 µM, 50 µM, 75 µM, 100 µM
Incubation Time:	20 hours
Result:	Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.

体内研究
(In Vivo)

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury^[2]
Dosage:	30 mg/kg, 300 mg/kg
Administration:	Oral gavage; daily; for 19 or 11 days
Result:	Significantly inhibited the progression of fibrosis throughout the lungs of the animals.

Clinical Trial

分子量

383.51

Formula

C₁₇H₁₈KN₃O₃S

CAS 号

161796-84-5

中文名称

埃索美拉唑钾盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17(3):439-46.

[2]. Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16.

[3]. Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Paromomycin sulfate salt 硫酸盐

发表于2023年11月9日由上海金畔生物科技有限公司

Paromomycin sulfate salt 硫酸盐

粉末，生物制剂，适用于细胞培养，≥98%

有货

CAS编号 1263-89-4 | 品牌：Jinpan

Paromomycin sulfate salt

MSDS

质检证书(CoA)

相似产品

分子式 C₂₃H₄₅N₅O₁₄·xH₂SO₄
PubChem编号 441375

货号 (SKU)	包装规格	是否现货	价格	数量
P431665-1g	1g	期货
P431665-5g	5g	期货

基本信息

产品名称	Paromomycin sulfate salt 硫酸盐
英文名称	Paromomycin sulfate salt
规格或纯度	粉末，生物制剂，适用于细胞培养，≥98%
生化机理	Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica , D. fragilis and several cestodes, like Taenia saginata , Taenia solium etc. Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

一般描述

General Description

Chemical structure: aminoglycoside Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon.

Application

Paromomycin sulfate salt has been used as a: reference compound in antileishmanial activity RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex. Recommended for use in cell culture applications at 100mg/L. Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI).

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place 1g,5g

General Description

Application

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place 1g,5g

Paromomycin sulfate salt 硫酸盐

发表于2023年11月9日由上海金畔生物科技有限公司

Paromomycin sulfate salt 硫酸盐

适用于植物细胞培养、生物制剂

有货

CAS编号 1263-89-4 | 品牌：Jinpan

Paromomycin sulfate salt

MSDS

质检证书(CoA)

相似产品

分子式 C₂₃H₄₅N₅O₁₄·xH₂SO₄
PubChem编号 441375

货号 (SKU)	包装规格	是否现货	价格	数量
P431666-5g	5g	期货
P431666-25g	25g	期货

基本信息

产品名称	Paromomycin sulfate salt 硫酸盐
英文名称	Paromomycin sulfate salt
规格或纯度	适用于植物细胞培养、生物制剂
生化机理	Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

一般描述

General Description

Chemical structure: aminoglycoside

Application

Paromomycin, monomycin, is an aminoglycoside antibiotic used to select genetically transformed plants and plant cells.

Other Notes

Keep container tightly closed in a dry and well-ventilated place

General Description

Chemical structure: aminoglycoside

Application

Paromomycin, monomycin, is an aminoglycoside antibiotic used to select genetically transformed plants and plant cells.

Other Notes

Keep container tightly closed in a dry and well-ventilated place

Penicillin G sodium salt 钠盐

发表于2023年11月9日由上海金畔生物科技有限公司

Penicillin G sodium salt 钠盐

96.0-102.0%

有货

CAS编号 69-57-8 | 品牌：Jinpan

Penicillin G sodium salt

MSDS

质检证书(CoA)

相似产品

分子式 C₁₆H₁₇N₂O₄SNa
分子量356.37

货号 (SKU)	包装规格	是否现货	价格	数量
P433334-5g	5g	期货
P433334-1g	1g	期货

基本信息

产品名称	Penicillin G sodium salt 钠盐
英文名称	Penicillin G sodium salt
别名	Benzylpenicillin sodium salt 钠盐
英文别名	Benzylpenicillin sodium salt
规格或纯度	96.0-102.0%
运输条件	冰袋运输
生化机理	Mode of Action: Inhibits bacterial cell wall synthesis. Antimicrobial spectrum: Gram-positive bacteria.

一般描述

General Description

Chemical structure: ß-lactam Penicillin G is a narrow spectrum natural antibiotic. It is effective against Streptococcus pneumoniae , groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus.

Application

Penicillin G has been used to study penicillin-binding protein 2, and non-toxigenic Corynebacterium diphtheriae isolated from cases of pharyngitis.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Product contains Penicillin.

General Description

Application

Penicillin G has been used to study penicillin-binding protein 2, and non-toxigenic Corynebacterium diphtheriae isolated from cases of pharyngitis.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Product contains Penicillin.

Penicillin G sodium salt 钠盐

发表于2023年11月9日由上海金畔生物科技有限公司

Penicillin G sodium salt 钠盐

粉末，生物制剂，适用于细胞培养

有货

CAS编号 69-57-8 | 品牌：Jinpan

Penicillin G sodium salt

MSDS

质检证书(CoA)

相似产品

分子式 C₁₆H₁₇N₂O₄SNa
分子量356.37

货号 (SKU)	包装规格	是否现货
P433335-25000000Units	25000000Units	期货
P433335-10000000Units	10000000Units	期货
P433335-1000000Units	1000000Units	期货
P433335-100000000Units	100000000Units	期货

基本信息

产品名称	Penicillin G sodium salt 钠盐
英文名称	Penicillin G sodium salt
别名	Benzylpenicillin sodium salt 钠盐
英文别名	Benzylpenicillin sodium salt
规格或纯度	粉末，生物制剂，适用于细胞培养
生化机理	Mode of Action: Inhibits bacterial cell wall synthesis. Antimicrobial spectrum: Gram-positive bacteria.

一般描述

General Description

Chemical structure: ß-lactam

Application

Penicillin G is a narrow spectrum natural antibiotic. It is effective against Streptococcus pneumoniae , groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. It has been used to study the diagnostic and therapeutic implications of gentamicin-resistant Enterococcus faecalis sequence type 6 with reduced penicillin susceptibility and in cell culture both alone and combined with streptomycin and other antibiotics.

Other Notes

1mu,10mu,25mu,100mu Keep container tightly closed in a dry and well-ventilated place.Product contains Penicillin Keep in a dry place.

General Description

Chemical structure: ß-lactam

Application

Other Notes

1mu,10mu,25mu,100mu Keep container tightly closed in a dry and well-ventilated place.Product contains Penicillin Keep in a dry place.

CAS编号	69-57-8
比旋光度	[α]D 300° (C=2,H2O)
熔点	209-212°C
储存温度	2-8°C储存
密度	1.41
分子量	356.37
分子式	C₁₆H₁₇N₂O₄SNa
品牌	Jinpan
备注	注意: Solutions should be filter sterilized and stored at Store at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days. The sodium salt is soluble in H 2 O at 100 mg/mL.
关联CAS	61-33-6

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Paromomycin sulfate salt 硫酸盐

基本信息

一般描述

相关属性

Paromomycin sulfate salt 硫酸盐

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一般描述

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Penicillin G sodium salt 钠盐

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Penicillin G sodium salt 钠盐

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