XY028-133

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XY028-133  纯度: 98.03%

XY028-133 (example 14) 是基于PROTAC 的 CDK4/6 的降解剂，由von Hippel-Lindau配体和CDK配体构成。

XY028-133

XY028-133 Chemical Structure

CAS No. : 2229974-73-4

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥5402 In-stock
5 mg ￥2900 In-stock
10 mg ￥4900 In-stock
25 mg ￥8900 In-stock
50 mg ￥15600 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

XY028-133 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Cell Cycle/DNA Damage Compound Library
  • Kinase Inhibitor Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Anti-Breast Cancer Compound Library
  • Anti-Pancreatic Cancer Compound Library
  • Anti-Blood Cancer Compound Library

生物活性

XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity, which consists of ligands for von Hippel-Lindau and CDK[1].

IC50 & Target[1]

CDK4

 

CDK6

 

体外研究
(In Vitro)

XY028-133 (1 and 3 μM, 24 h) significantly decreases CDK4/6, Cyclin A, PLK1 and pRb protein levels in A375 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1002.23

Formula

C53H67N11O7S
CAS 号

2229974-73-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (49.89 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9978 mL 4.9889 mL 9.9778 mL
5 mM 0.1996 mL 0.9978 mL 1.9955 mL
10 mM 0.0998 mL 0.4989 mL 0.9978 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. JIN, Jian， et al. COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER. Patent. US2017/065027.

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