KDM2A/7A-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

KDM2A/7A-IN-1  纯度: 99.57%

KDM2A/7A-IN-1 是一种首创、选择性、细胞通过性的组蛋白赖氨酸去甲基化酶 KDM2A/7A 抑制剂，对 KDM2A 的 IC50 值为 0.16 μM，对其选择性是对其他 JmjC 赖氨酸去甲基化酶的 75 倍，同时对甲基转移酶和组蛋白乙酰转移酶无作用。

KDM2A/7A-IN-1

KDM2A/7A-IN-1 Chemical Structure

CAS No. : 2169272-46-0

规格 价格 是否有货 数量
5 mg ￥8000 In-stock
10 mg ￥12800 In-stock
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KDM2A/7A-IN-1 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus

生物活性

KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16 μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases[1].

IC50 & Target

IC50: 0.16 μM (KDM2A)[1]
体外研究
(In Vitro)

KDM2A/7A-IN-1 ((S,S)-6) is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16 μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive to methyl transferases, and histone acetyl transferases[1].
KDM2A/7A-IN-1 (0.4, 3.1, 6.2 μM) augments cellular H3K36me2 levels in HeLa cells ectopically expressing catalytically active KDM2A[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

506.68

Formula

C33H38N4O
CAS 号

2169272-46-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Gerken PA, et al. Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7. Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15555-15559.

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