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GSTO-IN-2 纯度: ≥98.0%
GSTO-IN-2是一种谷胱甘肽S-转移酶 (glutathione S-transferase) 抑制剂,对于GSTA2,GSTM1和GSTP1-1的 IC50 值分别为3.6,16.3,1.4 μM。
GSTO-IN-2 Chemical Structure
CAS No. : 1202710-57-3
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥5500 | In-stock | |
10 mg | ¥8500 | In-stock | |
25 mg | ¥17500 | In-stock | |
50 mg | ¥27500 | In-stock | |
100 mg | ¥39500 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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GSTO-IN-2 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Metabolism/Protease Compound Library
- Anti-Cancer Compound Library
- Antioxidants Compound Library
- Oxygen Sensing Compound Library
- Anti-Breast Cancer Compound Library
- Targeted Diversity Library
生物活性 |
GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1. |
IC50 & Target |
IC50: 3.6 μM (GSTA2), 16.3 μM (GSTM1), 1.4 μM (GSTP1-1)[1] |
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体外研究 (In Vitro) |
GSTO-IN-2 is compound 3 in the reference. GSTO-IN-2 shows synergetic effect with chemotherapy drugs against two breast cancer cell lines through the inactivation of GST isozymes. The maximal enhancement of cisplatin-induced inhibition of cell viability is observed at 50 μM GSTO-IN-2, up to 640% against MCF-7 and up to 270% against MDA-MB-231. Viability inhibition of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), up to 170-320% against MCF-7 and up to 180-270% against MDA-MB-231.[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
620.77 |
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Formula |
C33H52N2O9 |
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CAS 号 |
1202710-57-3 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (161.09 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
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参考文献 |
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