(E/Z)-GO289

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

(E/Z)-GO289  纯度: 99.72%

(E/Z)-GO289 是一种有效且选择性的酪蛋白激酶 2 (CK2) 抑制剂 (IC50=7 nM)。(E/Z)-GO289 强烈延长昼夜节律周期。(E/Z)-GO289 表现出与细胞时钟功能相关的对癌细胞生长的细胞类型依赖性抑制。

(E/Z)-GO289

(E/Z)-GO289 Chemical Structure

CAS No. : 694522-87-7

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(E/Z)-GO289 相关产品

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生物活性

(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function[1].

体外研究
(In Vitro)

(E/Z)-GO289 is a potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.(E/Z)-GO289 shows an IC50 of 13 μM for PIM2 and is >1000 times higher than that for CK2[1].
(E/Z)-GO289 (3-9 μM; 2 days) strongly inhibits Caki-2, A498, and 769-P cells[1].
(E/Z)-GO289 enables manipulation of clock protein phosphorylation and cancer cell growth[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

419.30

Formula

C17H15BrN4O2S
CAS 号

694522-87-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Oshima T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv. 2019;5(1):eaau9060. Published 2019 Jan 23.

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