上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
AZM475271 (Synonyms: M475271) 纯度: 99.94%
AZM475271是Src激酶高效选择性抑制剂,IC50值为5nM,对Flt3、KDR和Tie-2抑制剂弱(IC50>10uM)。
AZM475271 Chemical Structure
CAS No. : 476159-98-5
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥1160 | In-stock | |
5 mg | ¥1050 | In-stock | |
10 mg | ¥1500 | In-stock | |
50 mg | ¥6100 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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AZM475271 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Kinase Inhibitor Library
- Protein Tyrosine Kinase Compound Library
- Anti-Cancer Compound Library
- Reprogramming Compound Library
- Anti-Pancreatic Cancer Compound Library
- Angiogenesis Related Compound Library
生物活性 |
AZM475271 is a potent and selective Src kinase inhibitor with IC50 of 5 nM; no inhibitory activity on Flt3, KDR, Tie-2. IC50 value: 5 nM [1] Target: Src inhibitor in vitro: AZM475271 demonstrated strong dose-dependent inhibition of Src tyrosine kinase activity in the L3.6pl human pancreatic carcinoma cell line. Maximum reduction of Src kinase activity was observed after incubation for 4 hours with ≥5 μmol/L. The IC50 concentration of AZM475271 to inhibit the phosphorylation of c-src, lck, and c-yes was 0.01, 0.03, and 0.08 μmol/L, respectively, in comparison with an IC50 of 0.7 μmol/L AZM475271 to inhibit KDR [2]. in vivo: Tumors appeared to be palpable at day 14 after tumor cell injection in all animals except mice treated with both AZM475271 and gemcitabine, in which the earliest possible palpation of the tumors was at day 17 after tumor cell injection. Treatment with gemcitabine or AZM475271 alone did not significantly change animal weight [2]. |
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分子量 |
442.94 |
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Formula |
C23H27ClN4O3 |
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CAS 号 |
476159-98-5 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 42 mg/mL (94.82 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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