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Ch55 纯度: 99.86%
Ch55 是一种有效的合成类维生素 A。Ch55 与 RAR-α 和 RAR-β 受体具有高亲和力。Ch55 对细胞视黄酸结合蛋白 (CRABP) 的亲和力较低。Ch55 是 HL60 细胞分化的有效诱导物,EC50 为 200 nM,可用于癌症的研究。
Ch55 Chemical Structure
CAS No. : 110368-33-7
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥2500 | In-stock | |
10 mg | ¥4250 | In-stock | |
25 mg | ¥8500 | 询价 | |
50 mg | 询价 | ||
100 mg | 询价 |
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Ch55 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Metabolism/Protease Compound Library
- Anti-Cancer Compound Library
- Differentiation Inducing Compound Library
- Reprogramming Compound Library
- Transcription Factor Targeted Library
- Targeted Diversity Library
生物活性 |
Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research[1][2]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
Ch55 inhibits squamous cell differentiation of rabbit tracheal epithelial cells by inhibiting type I transglutaminase activity (EC50 = 0.02 nM) and increasing cholesterol sulfate levels (EC50 = 0.03 nM). Ch55 also induce differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50s = 0.26 and 0.5 nM, respectively), and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM)[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
364.48 |
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Formula |
C24H28O3 |
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CAS 号 |
110368-33-7 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 50 mg/mL (137.18 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
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参考文献 |
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