S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate

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S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate  纯度: ≥95.0%

S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate 是一种谷胱甘肽可降解 (cleavable) 的 ADC linker,用于抗体偶联药物 (ADCs),属于 Alkyl-Chain 类,是 ADCs 用于 mAb 附着的连接体部分。

S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate

S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate Chemical Structure

CAS No. : 2127875-65-2

规格 价格 是否有货 数量
50 mg ¥4800 In-stock
100 mg ¥6800 In-stock
250 mg ¥9800 In-stock
500 mg   询价  
1 g   询价  

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生物活性

S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) and refers to the Alkyl-Chain composition. S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is the linker portions of the molecules employed for mAb attachment purposes[1].

IC50 & Target[1]

Cleavable

 

分子量

184.28

Formula

C5H12O3S2

CAS 号

2127875-65-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献
  • [1]. Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.

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