5-Hydroxy-7-acetoxyflavone

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

5-Hydroxy-7-acetoxyflavone 

5-Hydroxy-7-acetoxyflavone 是在各种植物来源中发现的具有活性的天然黄酮衍生物,可调节多种生物活性。

5-Hydroxy-7-acetoxyflavone

5-Hydroxy-7-acetoxyflavone Chemical Structure

CAS No. : 6674-40-4

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生物活性

5-Hydroxy-7-acetoxyflavone, an active natural flavone derivative found in various plant sources, modulates several biological activities[1].

分子量

296.27

Formula

C17H12O5

CAS 号

6674-40-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Apilak Worachartcheewan, et al. Probing the origins of anticancer activity of chrysin derivatives. Medicinal Chemistry Research. May 2015, 24(5):1884-1892.

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7-Hydroxy-4-methyl-8-nitrocoumarin

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

7-Hydroxy-4-methyl-8-nitrocoumarin 

7-Hydroxy-4-methyl-8-nitrocoumarin 是一种香豆素衍生物。

7-Hydroxy-4-methyl-8-nitrocoumarin

7-Hydroxy-4-methyl-8-nitrocoumarin Chemical Structure

CAS No. : 19037-69-5

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生物活性

7-Hydroxy-4-methyl-8-nitrocoumarin is a coumarin derivative[1].

分子量

221.17

Formula

C10H7NO5

CAS 号

19037-69-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Fadia Al-Haj Hussien, et al. Synthesis and Nitration of 7-Hydroxy-4-Methyl Coumarin via Pechmann Condensation Using Eco-Friendly Medias. International Letters of Chemistry, Physics and Astronomy. 2016, Vol. 69, pp 66-73.

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cis-4-Hydroxy-L-proline(Synonyms: 顺式-4-羟基-L-脯氨酸)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

cis-4-Hydroxy-L-proline (Synonyms: 顺式-4-羟基-L-脯氨酸) 纯度: ≥98.0%

cis-4-Hydroxy-L-proline,一种脯氨酸类似物,是胶原蛋白产生的抑制剂。cis-4-Hydroxy-L-proline 可通过阻止三层螺旋胶原在细胞层上的沉积从而抑制成纤维细胞的生长。cis-4-Hydroxy-L-proline 还可抑制原发性N-亚硝基甲基脲诱导的大鼠乳腺肿瘤的生长。

cis-4-Hydroxy-L-proline(Synonyms: 顺式-4-羟基-L-脯氨酸)

cis-4-Hydroxy-L-proline Chemical Structure

CAS No. : 618-27-9

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生物活性

cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4].

分子量

131.13

Formula

C5H9NO3

CAS 号

618-27-9

中文名称

顺式-4-羟基-L-脯氨酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 100 mg/mL (762.60 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 7.6260 mL 38.1301 mL 76.2602 mL
5 mM 1.5252 mL 7.6260 mL 15.2520 mL
10 mM 0.7626 mL 3.8130 mL 7.6260 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62.

    [2]. Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266(5597):63-4.

    [3]. Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80(4):261-7.

    [4]. Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):388-93.

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2-Hydroxy Ibuprofen(Synonyms: 2-羟基布洛芬; (±)-2-Hydroxy Ibuprofen)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

2-Hydroxy Ibuprofen (Synonyms: 2-羟基布洛芬; (±)-2-Hydroxy Ibuprofen)

2-Hydroxy Ibuprofen 是 Ibuprofen 的一种代谢产物。Ibuprofen 是 COX-1 和 COX-2 的抑制剂,IC50 值分别为 13 μM 和 370 μM,具有抗炎的活性。

2-Hydroxy Ibuprofen(Synonyms: 2-羟基布洛芬; (±)-2-Hydroxy Ibuprofen)

2-Hydroxy Ibuprofen Chemical Structure

CAS No. : 51146-55-5

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生物活性

2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.

分子量

222.28

Formula

C13H18O3

CAS 号

51146-55-5

中文名称

2-羟基布洛芬

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7.

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Hydroxy-PEG4-acid

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Hydroxy-PEG4-acid 

Hydroxy-PEG4-acid 是一种不可降解 (non-cleavable) 的含 4 个单元 PEG 的ADC linker,可用于合成抗体偶联药物 (ADC)。Hydroxy-PEG4-acid 还是一种 PROTAC linker,属于 PEG 类,可用于合成 PROTAC 分子。

Hydroxy-PEG4-acid

Hydroxy-PEG4-acid Chemical Structure

CAS No. : 937188-59-5

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生物活性

Hydroxy-PEG4-acid is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

Non-cleavable

 

PEGs

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

266.29

Formula

C11H22O7

CAS 号

937188-59-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Tinya Abrams, et al. Antibody drug conjugates. WO2016203432A1.

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Hydroxy-PEG2-C2-sulfonic acid

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Hydroxy-PEG2-C2-sulfonic acid 

Hydroxy-PEG2-C2-sulfonic acid 是一种 PROTAC linker,属于 PEG 类。Hydroxy-PEG2-C2-sulfonic acid 可用于合成一系列 PROTAC 分子。

Hydroxy-PEG2-C2-sulfonic acid

Hydroxy-PEG2-C2-sulfonic acid Chemical Structure

CAS No. : 112724-27-3

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生物活性

Hydroxy-PEG2-C2-sulfonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

IC50 & Target[1]

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

214.24

Formula

C6H14O6S

CAS 号

112724-27-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Upali Weersooriya, et al. Process for preparing isethionate ethoxylates. WO9529144A1

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Hydroxy-PEG10-Boc

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Hydroxy-PEG10-Boc 

Hydroxy-PEG10-Boc 来源于专利文献 CN108707228 (例 0024)。Hydroxy-PEG10-Boc 是一种用于合成抗体偶联药物 (ADC) 的不可降解 (non-cleavable) 的 ADC linker。Hydroxy-PEG10-Boc 可与紫杉醇 (HY-B0015) 或多西他赛 (HY-B0011) 结合。

Hydroxy-PEG10-Boc

Hydroxy-PEG10-Boc Chemical Structure

CAS No. : 778596-26-2

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生物活性

Hydroxy-PEG10-Boc is extacted from patent CN108707228 (example 0024)[1]. Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel (HY-B0015) or docetaxel (HY-B0011)[2].

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

586.71

Formula

C27H54O13

CAS 号

778596-26-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Huli, et al. A kind of preparation method of hydroxyl polyethylene glycol propionic ester. Patent CN108707228A.

    [2]. Miller ML, et al. Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery.J Med Chem. 2004 Sep 23;47(20):4802-5.

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N-Boc-cis-4-hydroxy-L-proline

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

N-Boc-cis-4-hydroxy-L-proline 

N-Boc-cis-4-hydroxy-L-proline 是不可降解 (non-cleavable) 的 ADC linker,用于合成抗体偶联药物 (ADCs)。N-Boc-cis-4-hydroxy-L-proline 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker,可用于合成 PROTAC。

N-Boc-cis-4-hydroxy-L-proline

N-Boc-cis-4-hydroxy-L-proline Chemical Structure

CAS No. : 87691-27-8

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生物活性

N-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2

IC50 & Target

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

231.25

Formula

C10H17NO5

CAS 号

87691-27-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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Hydroxy-PEG2-C2-PFP ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Hydroxy-PEG2-C2-PFP ester 

Hydroxy-PEG2-C2-PFP ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

Hydroxy-PEG2-C2-PFP ester

Hydroxy-PEG2-C2-PFP ester Chemical Structure

CAS No. : 1820673-42-4

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生物活性

Hydroxy-PEG2-C2-PFP ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

IC50 & Target

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

344.23

Formula

C13H13F5O5

CAS 号

1820673-42-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

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Hydroxy-PEG2-CH2-Boc

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Hydroxy-PEG2-CH2-Boc 

Hydroxy-PEG2-C2-PFP ester 是一种基于 PEG 和 Alkyl/ether 结构的 PROTAC linker。Hydroxy-PEG2-C2-PFP ester 可用于合成一系列 PROTAC 分子。

Hydroxy-PEG2-CH2-Boc

Hydroxy-PEG2-CH2-Boc Chemical Structure

CAS No. : 149299-82-1

规格 是否有货
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生物活性

Hydroxy-PEG2-CH2-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

220.26

Formula

C10H20O5

CAS 号

149299-82-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

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Hydroxy-PEG3-SS-PEG3-alcohol

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Hydroxy-PEG3-SS-PEG3-alcohol 

Hydroxy-PEG3-SS-PEG3-alcohol 是一种可降解 (cleavable) 的含 6 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

Hydroxy-PEG3-SS-PEG3-alcohol

Hydroxy-PEG3-SS-PEG3-alcohol Chemical Structure

CAS No. : 5662-81-7

规格 是否有货
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生物活性

Hydroxy-PEG3-SS-PEG3-alcohol is also a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

418.57

Formula

C16H34O8S2

CAS 号

5662-81-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Barrientos AG, et al. Gold glyconanoparticles: synthetic polyvalent ligands mimicking glycocalyx-like surfaces as tools for glycobiological studies. Chemistry. 2003 May 9;9(9):1909-21.

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6-Bromo-2-hydroxy-3-methoxybenzaldehyde(Synonyms: NSC95682)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

6-Bromo-2-hydroxy-3-methoxybenzaldehyde (Synonyms: NSC95682) 纯度: 99.55%

6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC95682) 是一个 IRE-1α 抑制剂,其 IC50 值为 0.08 μM,来自专利 WO 2008154484 A1, 实例 IRE-lα 抑制剂化合物 3-5。

6-Bromo-2-hydroxy-3-methoxybenzaldehyde(Synonyms: NSC95682)

6-Bromo-2-hydroxy-3-methoxybenzaldehyde Chemical Structure

CAS No. : 20035-41-0

规格 价格 是否有货 数量
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生物活性

6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC95682) is an IRE-1α inhibitor with an IC50 of 0.08 μM, extracted from patent WO 2008154484 A1, IRE-lα inhibitor compound 3-5.

IC50 & Target

IC50: 0.08 μM (IRE-1α)[1]

分子量

231.04

Formula

C8H7BrO3

CAS 号

20035-41-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 113 mg/mL (489.09 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.3283 mL 21.6413 mL 43.2826 mL
5 mM 0.8657 mL 4.3283 mL 8.6565 mL
10 mM 0.4328 mL 2.1641 mL 4.3283 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. John Bruce Patterson, et al. Ire-1a inhibitors. WO 2008154484 A1

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Hydroxy-PEG12-Boc

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Hydroxy-PEG12-Boc 

Hydroxy-PEG12-Boc 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Hydroxy-PEG12-Boc

Hydroxy-PEG12-Boc Chemical Structure

CAS No. : 2388521-20-6

规格 是否有货
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500 mg   询价  

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生物活性

Hydroxy-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

674.81

Formula

C31H62O15

CAS 号

2388521-20-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

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Hydroxy-PEG13-Boc

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Hydroxy-PEG13-Boc 

Hydroxy-PEG13-Boc 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Hydroxy-PEG13-Boc

Hydroxy-PEG13-Boc Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Hydroxy-PEG13-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

718.87

Formula

C33H66O16

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Hydroxy-PEG16-Boc

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Hydroxy-PEG16-Boc 

Hydroxy-PEG16-Boc 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Hydroxy-PEG16-Boc

Hydroxy-PEG16-Boc Chemical Structure

CAS No. : 2592433-80-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Hydroxy-PEG16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

851.03

Formula

C39H78O19

CAS 号

2592433-80-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Hydroxy-PEG24-Boc

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Hydroxy-PEG24-Boc 

Hydroxy-PEG24-Boc 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Hydroxy-PEG24-Boc

Hydroxy-PEG24-Boc Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Hydroxy-PEG24-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1203.45

Formula

C55H110O27

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

7-Hydroxy-4H-chromen-4-one(Synonyms: 7-Hydroxychromone)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

7-Hydroxy-4H-chromen-4-one (Synonyms: 7-Hydroxychromone) 纯度: 99.83%

7-Hydroxychromone 是一个 Src 激酶抑制剂,其 IC50 值小于 300 μM。

7-Hydroxy-4H-chromen-4-one(Synonyms: 7-Hydroxychromone)

7-Hydroxy-4H-chromen-4-one Chemical Structure

CAS No. : 59887-89-7

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥550 In-stock
50 mg ¥500 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

7-Hydroxy-4H-chromen-4-one 相关产品

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  • Angiogenesis Related Compound Library
  • Targeted Diversity Library

生物活性

7-Hydroxychromone is a Src kinase inhibitor with an IC50 of <300 μM.

IC50 & Target

IC50: <300 μm (src)[1]

体外研究
(In Vitro)

7-Hydroxychromone (compound 8) is a 4-oxo-4H-1-benzopyran derivative which can inhibit Src kinase with an IC50 of <300 μm[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

162.14

Formula

C9H6O3

CAS 号

59887-89-7

中文名称

7-羟基色原酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 14.29 mg/mL (88.13 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.1675 mL 30.8375 mL 61.6751 mL
5 mM 1.2335 mL 6.1675 mL 12.3350 mL
10 mM 0.6168 mL 3.0838 mL 6.1675 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.43 mg/mL (8.82 mM); Clear solution

    此方案可获得 ≥ 1.43 mg/mL (8.82 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 14.3 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 1.43 mg/mL (8.82 mM); Suspended solution; Need ultrasonic

    此方案可获得 1.43 mg/mL (8.82 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 14.3 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Karam Chand, et al. Synthesis, Antiproliferative, and c-Src Kinase Inhibitory Activities of 4-Oxo-4H-1-benzopyran Derivatives. ‎J. Heterocycl. Chem. 2014.

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Hydroxy-PEG2-CH2COOH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Hydroxy-PEG2-CH2COOH 

Hydroxy-PEG2-CH2COOH 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Hydroxy-PEG2-CH2COOH

Hydroxy-PEG2-CH2COOH Chemical Structure

CAS No. : 51951-04-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Hydroxy-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

164.16

Formula

C6H12O5

CAS 号

51951-04-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Hydroxy-PEG4-CH2COOH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Hydroxy-PEG4-CH2COOH 

Hydroxy-PEG4-CH2COOH 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Hydroxy-PEG4-CH2COOH

Hydroxy-PEG4-CH2COOH Chemical Structure

CAS No. : 70678-95-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

252.26

Formula

C10H20O7

CAS 号

70678-95-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Hydroxy-PEG4-C2-nitrile

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Hydroxy-PEG4-C2-nitrile 

Hydroxy-PEG4-C2-nitrile 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Hydroxy-PEG4-C2-nitrile

Hydroxy-PEG4-C2-nitrile Chemical Structure

CAS No. : 2194563-83-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Hydroxy-PEG4-C2-nitrile is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

247.29

Formula

C11H21NO5

CAS 号

2194563-83-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务