(S,R,S)-AHPC-PEG3-N3(Synonyms: VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12)

发表于由

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(S,R,S)-AHPC-PEG3-N3 (Synonyms: VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12)

(S,R,S)-AHPC-PEG3-N3 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 3 个单元 PEG linker。

(S,R,S)-AHPC-PEG3-N3(Synonyms: VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12)

(S,R,S)-AHPC-PEG3-N3 Chemical Structure

CAS No. : 1797406-80-4

规格 价格 是否有货 数量
50 mg ￥2200 In-stock
100 mg ￥3100 In-stock
500 mg ￥12000 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

生物活性

(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

IC50 & Target

VHL

 

体外研究
(In Vitro)

(S,R,S)-AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1, figure 11. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker[1][2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

645.77

Formula

C30H43N7O7S
CAS 号

1797406-80-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

Ethanol : 100 mg/mL (154.85 mM; Need ultrasonic)

DMSO : 50 mg/mL (77.43 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5485 mL 7.7427 mL 15.4854 mL
5 mM 0.3097 mL 1.5485 mL 3.0971 mL
10 mM 0.1549 mL 0.7743 mL 1.5485 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. CIULLI, Alessio, et al. DERIVATIVES OF 1-[(CYCLOPENTYL OR 2-PYRROLIDINYL)CARBONYLAMINOMETHYL]-4-(1,3-THIAZOL-5-YL) BENZENE WHICH ARE USEFUL FOR THE TREATMENT OF PROLIFERATIVE, AUTOIMMUNE OR INFLAMMATORY DISEASES. WO2016146985A1.

    [2]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.

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