Alendronic acid

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Alendronic acid  纯度: ≥98.0%

Alendronic acid，一种双膦酸盐，是法呢基二磷酸合酶 (FDPS) 抑制剂。Alendronic acid 抑制破骨细胞介导的骨吸收。Alendronic acid 对绝经后骨质疏松症，恶性高钙血症和 Paget 病具有疗效。

Alendronic acid

Alendronic acid Chemical Structure

CAS No. : 66376-36-1

规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥940 In-stock
100 mg ￥850 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease[1].

体外研究
(In Vitro)

Bisphosphonates are widely used in the treatment of osteoporosis, and among the bisphosphonates, alendronic acid is the most frequently prescribed drug. Bisphosphonates have powerful inhibitory effects on bone remodeling, a process that is critically important for fracture healing[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

249.10

Formula

C4H13NO7P2
CAS 号

66376-36-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 8.33 mg/mL (33.44 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.0145 mL 20.0723 mL 40.1445 mL
5 mM 0.8029 mL 4.0145 mL 8.0289 mL
10 mM 0.4014 mL 2.0072 mL 4.0145 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Teixeira S, et al. Alendronic Acid as Ionic Liquid: New Perspective on Osteosarcoma. Pharmaceutics. 2020 Mar 24;12(3). pii: E293.

    [2]. Duckworth AD, et al. Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial. J Bone Miner Res. 2019 Jun;34(6):1025-1032.

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