上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
ARP-100 纯度: ≥98.0%
ARP-100 是一种有效的选择性基质金属蛋白酶 MMP-2 抑制剂 (IC50=12 nM)。ARP-100 与 MMP-2 的 S1' 口袋相互作用,并在体外对基质胶的侵袭模型中显示抗侵袭特性。ARP-100 对 MMP-1 (>50 μM),MMP-3 (4.5 μM),MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。
ARP-100 Chemical Structure
CAS No. : 704888-90-4
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥1320 | In-stock | |
5 mg | ¥1200 | In-stock | |
10 mg | ¥2000 | In-stock | |
25 mg | ¥3900 | In-stock | |
50 mg | ¥6500 | In-stock | |
100 mg | ¥10000 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
ARP-100 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
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- Anti-Cancer Compound Library
- Differentiation Inducing Compound Library
- Anti-Pancreatic Cancer Compound Library
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- Targeted Diversity Library
生物活性 |
ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1' pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM)[1][2]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
ARP-100 (50 nM) shows a significant reduction in the total number of invasive elongations[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
364.42 |
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Formula |
C17H20N2O5S |
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CAS 号 |
704888-90-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (274.41 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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