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MD2-TLR4-IN-1 纯度: 99.69%
MD2-TLR4-IN-1 (compound 22m) 是 MD2-TLR4 复合体的抑制剂,能够抑制巨噬细胞 LPS 诱导的 TNF-α 和 IL-6 的表达,IC50 值分别为 0.89 μM 和 0.53 μM。
MD2-TLR4-IN-1 Chemical Structure
CAS No. : 2249801-12-3
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥3240 | In-stock | |
5 mg | ¥3500 | In-stock | |
10 mg | ¥5500 | In-stock | |
25 mg | ¥9900 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
* Please select Quantity before adding items.
MD2-TLR4-IN-1 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Immunology/Inflammation Compound Library
- Anti-Cancer Compound Library
- Small Molecule Immuno-Oncology Compound Library
- Antioxidants Compound Library
- Differentiation Inducing Compound Library
- Oxygen Sensing Compound Library
- Pyroptosis Compound Library
- Anti-Obesity Compound Library
生物活性 |
MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1]. |
IC50 & Target |
MD2-TLR4[1]. |
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分子量 |
421.28 |
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Formula |
C22H14Cl2N4O |
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CAS 号 |
2249801-12-3 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 83.33 mg/mL (197.80 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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