Aminopterin(Synonyms: 氨基蝶呤; 4-Aminofolic acid; APGA)

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Aminopterin (Synonyms: 氨基蝶呤; 4-Aminofolic acid; APGA) 纯度: 98.02%

Aminopterin (4-Aminofolic acid)，叶酸的 4-氨基衍生物，是叶酸 (folic acid) 拮抗剂。Aminopterin 催化叶酸还原为四氢叶酸，Aminopterin 竞争性抑制二氢叶酸还原酶 (DHFR)，Ki 值为 3.7 pM。Aminopterin 具有抗癌和免疫抑制活性。Aminopterin 用于研究儿童白血病。

Aminopterin(Synonyms: 氨基蝶呤; 4-Aminofolic acid; APGA)

Aminopterin Chemical Structure

CAS No. : 54-62-6

规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥715 In-stock
5 mg ￥650 In-stock
10 mg ￥1000 In-stock
50 mg   询价  
100 mg   询价  

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生物活性

Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia[1][2].

体外研究
(In Vitro)

The IC50 value of Aminopterin (4-Aminofolic acid) against CCRF-CEM cells during 72 h of exposure is 4.4 nM[2].
Aminopterin (4-Aminofolic acid) produces a marked inhibition of mitosis in low concentrations in human leukemic leukocytes[4].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

440.41

Formula

C19H20N8O5
CAS 号

54-62-6
中文名称

氨基蝶呤
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 14.71 mg/mL (33.40 mM; Need ultrasonic)

H2O : 5 mg/mL (11.35 mM; ultrasonic and adjust pH to 8 with NaOH)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2706 mL 11.3531 mL 22.7061 mL
5 mM 0.4541 mL 2.2706 mL 4.5412 mL
10 mM 0.2271 mL 1.1353 mL 2.2706 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. MEYER LM, et al. Aminopterin, a folic acid antagonist, in the treatment of leukemia. Am J Clin Pathol. 1949 Feb;19(2):119-26.

    [2]. Rosowsky A, et al. Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues. J Med Chem. 2004 Dec 30;47(27):6958-63.

    [3]. Gebhardt DO, et al. The influence of aminopterin on limb regeneration in Ambystoma mexicanum. J Embryol Exp Morphol. 1966 Aug;16(1):143-58.

    [4]. F. W Gtmrz, et al. THE EFFECT OF 4-AMINO-PTEROYLGLUTAMIC ACID (AMINOPTERIN) ON HUMAN LEUKEMIC LEUKOCYTES IN VITRO. Blood (1950) 5 (2): 161-166.

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